影响促排卵周期人工授精临床妊娠率的因素分析  

Analysis on the factors affecting the pregnancy rate of ovulatory cycle artificial insemination

作　　者：周知[1] 马宁[1] 涂志华[1] 李海波[2] ZHOU Zhi;MA Ning;TU Zhihua;LI Haibo(Hainan Maternal and Child Health Hospital,Hainan Province,Haikou570206,China;Suzhou Hospital Affiliated to Nanjing Medical University,Jiangsu Province,Suzhou215000,China)

机构地区：[1]海南省妇幼保健院,海南海口570206 [2]南京医科大学附属苏州医院,江苏苏州215000

出　　处：《中国医药导报》2020年第15期104-107,共4页China Medical Herald

基　　金：海南省重点研发计划项目(ZDYF2017086)。

摘　　要：目的分析影响促排卵周期宫腔内人工授精(IUI)成功率的因素。方法回顾性分析2015年7月~2017年6月在海南省妇幼保健院和南京医科大学附属苏州医院行促排卵IUI的500个周期及其患者的临床资料,探讨女性年龄、不孕年限、IUI周期次数、每个周期中的IUI次数、促排卵方案、优势卵泡数目、人绒毛膜促性腺激素(HCG)诱导排卵与否等指标与临床妊娠率的相关性,通过logistic回归分析确定IUI临床妊娠率的独立影响因素。结果经过IUI共有117例患者成功妊娠,妊娠率为23.40%;单因素分析结果显示,女性年龄和优势卵泡数目对于IUI临床妊娠率有显著影响(P<0.05),而不孕年限、IUI周期次数、每个周期中的IIUI次数、促排卵方案、HCG诱导排卵与否对于IUI临床妊娠率无影响(P>0.05)。logistic回归分析显示,女性年龄(OR=2.128、95%CI:1.018~4.162,P<0.05)和优势卵泡数目(OR=3.617、95%CI:0.855~7.282,P<0.05)是促排卵周期IUI临床妊娠率的独立影响因素。结论女性年龄和优势卵泡数目是影响促排卵周期IUI临床妊娠率的关键因素,年龄是危险因素,优势卵泡数目是保护因素。Objective To analysis the influencing factors of success rate of intrauterine artificial insemination(IUI)in ovulation-promoting cycle.Methods A retrospective analysis of 500 cycles of ovulation-promoting IUI and clinical data of patients at Hainan Maternal and Child Health Hospital and Suzhou Hospital Affiliated to Nanjing Medical University from July 2015 to June 2017,the female age,infertility years,IUI cycle,the number of IUI times per cycle,the number of ovulation inducing scheme,the number of dominant follicles,and whether or not human chorionic gonadotropin(HCG)inducing ovulation and its correlation with the clinical pregnancy rate were explored.The independent factors affecting clinical pregnancy rate of IUI were analyzed by logistic regression analysis.Results A total of 117 patients were successfully pregnant after IUI,with a pregnancy rate of 23.40%.The univariate analysis showed that the effect of female age and the number of dominant follicles on the clinical pregnancy rate of IUI was significant(P<0.05),there were no statistically significant differences in the effects of infertility years,IUI cycles,the number of IUI in each cycle,the ovulation-promoting regimen,and whether or not HCG induced ovulation on the clinical pregnancy rate of IUI(P>0.05).logistic regression analysis showed that the age of women(OR=2.128,95%CI:1.018-4.162,P<0.05)and the number of dominant follicles(OR=3.617,95%CI:0.855-7.282,P<0.05)were independent influencing factors of the clinical pregnancy rate of IUI in the ovulation-promoting cycle.Conclusion Female age and the number of dominant follicles are key factors in the clinical pregnancy rate of the IUI during the ovulation-promoting cycle,age is a risk factor,and the number of dominant follicles is a protective factor.

关 键 词：人工授精 促排卵 临床妊娠率 危险因素 保护因素 

分 类 号：R711.4[医药卫生—妇产科学]