水飞蓟宾胶囊对代谢综合征患者代谢指标及血管内皮功能的影响  

Effect of Silibinin Capsules on metabolic index and vascular endothelial function in patients with metabolic syndrome

作　　者：檀时新[1] 李鸣[2] TAN Shixin;LI Ming(Department of Medicine,Nanjing Hospital of Traditional Chinese Medicine,Jiangsu Province,Nanjing210006,China;Department of Endocrinology,Nanjing Hospital of Traditional Chinese Medicine,Jiangsu Province,Nanjing210006,China)

机构地区：[1]南京市中医院药学部,江苏南京210006 [2]南京市中医院内分泌科,江苏南京210006

出　　处：《中国医药导报》2020年第15期131-134,共4页China Medical Herald

摘　　要：目的研究水飞蓟宾胶囊对代谢综合征患者代谢指标及血管内皮功能的影响。方法纳入2017年6月~2019年6月南京市中医院治疗的82例代谢综合征患者为研究对象,按随机数字表法分为对照组和观察组,各41例,对照组接受基础治疗,观察组在对照组基础上加用水飞蓟宾胶囊。比较两组治疗前后血管内皮功能指标:基础血管内径值(D0)、充血血管内径(D1)、血管内皮依赖性舒张功能(FMD);代谢指标:体重指数(BMI)、腰围(WC)、三酰甘油(TG)、总胆固醇(TC)、空腹胰岛素(FINS)、空腹血糖(FBG)及葡萄糖代谢率(M);血清炎性因子及肝功能指标:血清白细胞介素-8(IL-8)、IL-18、肿瘤坏死因子-α(TNF-α)及丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)。结果治疗后,两组FMD、D0、D1均显著高于治疗前,且观察组高于对照组(P<0.05)。两组TG、FINS水平均显著低于治疗前,且观察组低于对照组(P<0.05),两组M值均显著高于治疗前,且观察组高于对照组(P<0.05)。两组IL-18、IL-8、TNF-a、ALT、AST水平均显著低于治疗前,且观察组低于对照组(P<0.05)。结论水飞蓟宾胶囊可有效调节代谢综合征患者代谢紊乱,改善血管内皮功能。Objective To study the effect of Silibinin Capsules on metabolic index and vascular endothelial function in patients with metabolic syndrome.Methods From June 2017 to June 2019,a total of 82 patients with metabolic syndrome admitted to Nanjing Hospital of Traditional Chinese Medicine were included in the study.According to the random number table method,they were divided into control group and observation group,41 cases in each group,the control group received basic treatment,and the observation group added Silibinin Capsules on the basis of the control group.Before and after treatment,the endothelium function indexes of the two groups were compared,basic vessel diameter(D0),congestive vessel diameter(D1),endothelium-dependent vasodilation(FMD);metabolism indexes;body mass index(BMI),waist circumference(WC),triglyceride(TG),total cholesterol(TC),fasting insulin(FINS),fasting blood glucose(FBG)and glucose metabolism rate(M);serum Inflammatory factors and liver function indexes:serum interleukin-8(IL-8),IL-18,tumor necrosis factor-α(TNF-α),alanine aminotransferase(ALT),aspartate aminotransferase(AST).Results After treatment,FMD,D0 and D1 in the two groups were significantly higher than before treatment,and the observation group was significantly higher than the control group(P<0.05).The TG and FINS levels in both groups were significantly lower than those before treatment,and the observation group was lower than the control group(P<0.05).The M value in both groups was significantly higher than that before treatment,and the value in the observation group was higher than that in the control group(P<0.05).The levels of IL-18,IL-8,TNF-α,ALT and AST in both groups were significantly lower than those before treatment,and were lower in the observation group than in the control group(P<0.05).Conclusion Silibinin Capsules can effectively regulate metabolic disorder and improve endothelial function in patients with metabolic syndrome.

关 键 词：代谢综合征 水飞蓟宾胶囊 代谢指标 血管内皮功能 

分 类 号：R589[医药卫生—内分泌]