基于关联规则与聚类分析探索中药外治手足综合征的用药规律  

Exploration on the rule of traditional Chinese medicine in external treatment of hand foot syndrome based on association rule and cluster analysis

作　　者：于然[1,2] 贾立群[2] 娄彦妮 YU Ran;JIA Liqun;LOU Yanni(Internal Oncology Department of Integrated Traditional Chinese and Western Medicine,China-Japan Friendship Hospital of Health Ministry,Beijing100029,China;Beijing University of Chinese Medicine,Beijing100029,China)

机构地区：[1]卫生部中日友好医院中西医结合肿瘤内科,北京100029 [2]北京中医药大学,北京100029

出　　处：《中国医药导报》2020年第15期139-142,共4页China Medical Herald

基　　金：国家科技支撑计划课题(2015BAI04B07);北京市科技计划课题(Z171100001017207)。

摘　　要：目的挖掘中药外用治疗手足综合征(HFS)的组方规律。方法以“手足综合征”或“手足皮肤反应”为关键词在万方数据库、中国知网、维普网检索2019年9月之前的所有文献,筛选中药外治组方,使用Excel 2019进行数据录入,对组方中的中药进行频数统计分析,对高频中药使用R语言3.6.0的“arules”包进行关联规则分析,寻找关联性较强的中药组合。此外SPSS 20.0对高频中药进行聚类分析,得出治疗HFS最主要的功效集合。结果共纳入80个外治组方,使用频率>10次的中药有15味。关联规则分析产生关联性最强的药对有11个,药物间关联性最强的中药有4味:黄芪、红花、桂枝、当归。聚类分析将高频中药主要聚为两类:益气活血、温经通络。结论中药外用治疗HFS主要以益气活血、温经通络为主,同时配合清热解毒、养血润燥。Objective To search and analyze medication rules of traditional Chinese medicine(TCM)for hand foot syndrome(HFS).Methods Articles were searched from CNKI,Wanfang data and VIP network by the words of“hand foot syndrome”or“hand foot skin reaction”before September 2019.The formulas of external use for HFS was screened,and the data was logged in excel 2019.The association rules were conducted using“arules”of R 3.6.0 to search for TCM composition with strong association and cluster analysis was conducted by SPSS 20.0 for herbs of high frequency to research main combination of TCM for HFS.Results Eighty TCM formulas was included.There were 15 herbs that using frequency was more than 10.According to medication rules,11 herb-partners had strong combination.Herbs which had the most strong internal relationship were Radix Astragali seu Hedysari,Flos Carthami,Ramulus Cinnamomi,Radix Angelicae Sinensis.Cluster analysis produced two main treatment aspects:benefiting qi for activating blood circulation,warming womb and channels and dredging channels.Conclusion The external application of TCM in treating HFS is mainly through benefiting qi for activating blood circulation,warming womb and channels and dredging channels,as well as clearing heat and removing toxicity and nourishing blood for moistening dryness.

关 键 词：中药组方 外治 手足综合征 关联规则 数据挖掘 用药规律 

分 类 号：R242[医药卫生—中医临床基础]