益气养阴活血利水法联合康柏西普对非增殖期糖尿病视网膜病变患者视网膜电图的影响  

Effect of Yiqi Yangyin Huoxue Lishui combined with conbercept on electroretinogram in non-proliferative diabetic retinopathy

作　　者：刘培 彭俊[2] 李书楠 曾志成 覃艮艳 姚小磊[2] 陈向东[2] 蒋鹏飞[1] 彭清华[1] LIU Pei;PENG Jun;LI Shunan(Hunan University of Chinese Medicine,Changsha 410208)

机构地区：[1]湖南中医药大学,长沙410208 [2]湖南中医药大学第一附属医院,长沙410007 [3]湖南省桂阳县第一人民医院,郴州424400 [4]湖南省常德市第一中医院,常德415000

出　　处：《陕西中医》2020年第6期728-732,共5页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81804150,81603664);中医药防治眼耳鼻咽喉疾病与视功能保护湖南省工程技术研究中心建设项目(2018TP2008)。

摘　　要：目的:观察益气养阴活血利水法联合康柏西普对非增殖期糖尿病视网膜病变(NPDR)患者视网膜电图(ERG)的影响。方法:60例(82眼)NPDR患者,采用随机数字表法分为两组,对照组30例(40眼)玻璃体腔注射康柏西普,每月1次,治疗组30例(42眼)在对照组的基础上加用益气养阴活血利水中药口服治疗。治疗3个月后,观察两组患者BCVA、ERG,OCT检测两组患者CMT情况。结果:两组患者治疗前后不同时间BCVA、暗适应及明适应ab波振幅、CMT差异有统计学意义(P<0.05),治疗后不同时间两组患者BCVA、明暗适应ab波振幅、CMT相比,差异均有统计学意义(P<0.05)。结论:益气养阴活血利水法联合康柏西普较单纯康柏西普治疗能更好的减轻NPDR患者视网膜水肿,提高视力、暗适应及明适应a、b波振幅,降低CMT。Objective:To observe the effect of Yiqi Yangyin Huoxue Lishui combined with conbercept on ERG in NPDR.Methods:60 patients(82 eyes)with NPDR were randomly divided into two groups,30 patients in the control group(40 eyes)with intravitreal injection of conbercept,once a month,and 30 patients in the treatment group(42 eyes)in the control group.On the basis of the addition of Yiqi Yangyin Huoxue Lishui oral treatment.After 3 months of treatment,BCVA and ERG,OCT were used to detect the CMT of the two groups.Results:There were significant differences in BCVA,a-b wave amplitudes of dark adaptation and bright adaptation amplitude and CMT between the two groups before and after treatment(P<0.05).There were significant differences in BCVA,a-b wave amplitudes of dark adaptation and a-b wave amplitude and CMT between the two groups after treatment(P<0.05).Conclusion:Compared with conbercept,it can better reduce retinal edema in NPDR patients,improve visual acuity,dark adaptation and bright adaptation,reduce CMT.

关 键 词：益气养阴 活血利水 非增殖期糖尿病视网膜病变 康柏西普 视网膜电图 血管内皮生长因子 

分 类 号：R256[医药卫生—中医内科学]