血浆致动脉硬化指数在绝经后女性冠心病中的预测价值  

Predictive value of atherogenic index of plasma in postmenopausal women with coronary heart disease

作　　者：杨新宇 鲍百丽[2] Yang Xinyu;Bao Baili(Postgraduate Training of Jinzhou Central Hospital, Jinzhou Medical University, Jinzhou 121000, China;Department of Cardiology, Jinzhou Central Hospital, Jinzhou 121000, China)

机构地区：[1]锦州医科大学锦州市中心医院研究生培养基地,辽宁锦州121000 [2]锦州市中心医院心内科,辽宁锦州121000

出　　处：《临床荟萃》2020年第7期599-603,共5页Clinical Focus

摘　　要：目的探讨血浆致动脉硬化指数(atherogenic index of plasma,AIP)在绝经后女性冠心病中的预测价值。方法采用回顾性分析方法,收集疑诊冠心病于我院住院并行冠状动脉造影的绝经后女性患者233例,根据造影结果分为冠心病组(n=171)和对照组(n=62)。比较两组间AIP的差异;应用二元Logistic回归分析绝经后女性冠心病的独立危险因素,并分析AIP对绝经后女性冠心病的预测价值。结果冠心病组AIP水平明显高于对照组(P<0.01)。二元Logistic回归分析显示高AIP水平、低雌二醇(E2)、高血压可作为评估绝经后女性冠心病的独立危险因素(OR=8.784,P=0.002,95%CI:2.170~35.558;OR=0.813,P=0.000,95%CI:0.764~0.865;OR=2.151,P=0.037,95%CI:1.046~4.422)。ROC曲线分析校正AIP预测冠心病的最佳临界值是2.02,敏感度为66.7%,特异度为64.5%。结论高AIP水平、低E2可作为绝经后女性冠心病的独立危险因素,AIP可用于预测绝经后女性冠心病,当校正AIP>2.02时,可认为存在冠心病的风险。Objective To investigate the predictive value of atherogenic index of plasma(AIP)in postmenopausal women with coronary heart disease(CHD).Methods A retrospective analysis method was used to select 233 postmenopausal women who were with suspected CHD and underwent coronary angiography in our hospital.The patients were divided into CHD group(n=171)and control group(n=62)according to the results of coronary angiography.The differences of AIP between two groups were compared.Binary logistic regression was used to analyze the independent risk factors for postmenopausal women with CHD.And the predictive value of AIP for postmenopausal women with CHD was analyzed.Results The AIP levels in CHD group were significantly higher than those in control group(P<0.01).Binary Logistic regression analysis showed that high AIP,low estradiol(E2),and hypertension were independent risk factors for postmenopausal women with CHD(OR=8.784,P=0.002,95%CI:2.170-35.558;OR=0.813,P=0.000,95%CI:0.764-0.865;OR=2.151,P=0.037,95%CI:1.046-4.422).The ROC curve analysis showed that the optimal threshold for adjusted AIP to predict CHD was 2.02,with sensitivity 66.7%and specificity 64.5%.Conclusion The high AIP levels and low estradiol level can be independent risk factors for postmenopausal women with CHD.AIP can be used to predict CHD in postmenopausal women.When adjusted AIP is more than 2.02,there is a risk of CHD.

关 键 词：动脉硬化 冠心病 冠状动脉造影术 绝经后期 女性 

分 类 号：R541.4[医药卫生—心血管疾病]