哮喘儿童睡眠紊乱和注意缺陷多动障碍特征及相关性研究  

Characteristics and correlation of sleep disorder and attention deficit hyperactivity disorder in children with asthma

作　　者：谢庆玲[1] 刘淑君 秦岭[2] 秦海娇[2] 谭颖[1] 张迪雯 黎重清[1] 陈泓伶[1] 庞小容 Xie Qingling;Liu Shujun;Qin Ling;Qin Haijiao;Tan Ying;Zhang Diwen;Li Zhongqing;Chen Hongling;Pang Xiaorong(Department of Pediatrics,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Cognitive Sleep Center,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院儿科,广西南宁530021 [2]广西壮族自治区人民医院认知睡眠中心,广西南宁530021

出　　处：《临床荟萃》2020年第7期633-638,共6页Clinical Focus

基　　金：广西自然科学基金项目注意缺陷多动障碍哮喘儿童脑功能及相关影响因素的研究(桂科自2013GXNSFAA019266);广西卫健委科研课题哮喘儿童睡眠紊乱与注意力缺陷关系的临床研究(Z20170302)。

摘　　要：目的探讨哮喘患儿睡眠障碍与注意缺陷多动障碍的特点及关联性。方法选择6~14岁哮喘慢性持续期患儿35例,通过肺功能及哮喘控制测试评分(ACT)分为哮喘基本控制组和未控制组。对患儿进行儿童睡眠紊乱量表评分和夜间睡眠监测,并完成视听整合持续操作测试(IVA-CPT)和戴斯-纳格利尔里认知评估系统(D-N:CAS)检测。结果两组的儿童睡眠紊乱量表(SDSC)总粗分、入睡或维持睡眠障碍、睡眠-觉醒转换障碍、睡眠出汗过多指标比较差异有统计学意义(P<0.01)。夜间睡眠监测参数多项指标两组比较差异有统计学意义(P<0.05)。IVA-CPT检测哮喘未控制组综合反应控制力商数(FSCQ)、综合注意力商数(FSAQ)较哮喘基本控制组明显减低(P<0.01);D-N:CAS参数指标中哮喘基本控制组和哮喘未控制组患儿的计划力(PLAN)、同时性加工能力(SIM)、注意力(ATT)、继时性加工能力(SUC)、认知水平得分(FS),比较均有统计学意义(P<0.05)。IVA-CPT指标中FSCQ、FSAQ和D-N:CAS中PLAN、SIM、ATT、SUC、FS与睡眠参数中的SDSC总粗分、入睡或维持障碍、睡眠-觉醒转换障碍、AHI呈负相关(均P<0.05),与睡眠效率、最低血氧呈正相关(均P<0.05)。结论哮喘患儿易出现睡眠结构紊乱和注意缺陷多动障碍,两者存在关联性影响。Objective To explore the characteristics and correlation of sleep disorders and attention deficit hyperactivity disorder in children with asthma.Methods Thirty-five children aged 6 to 14 with chronic duration of asthma were selected and divided into asthma basic control group and asthma non-control group according to the lung function and asthma control test(ACT)scores.The children's sleep disorder scale was scored and their night-time sleep monitoring was performed.The integrated visual and auditory continuous performance test(IVA-CPT)and Das-Naglieri cognitive assessment system(D-N:CAS)were completed.Results There were significant differences in the indicators of Sleep Disturbances Scale for Children(SDSC)total score,disorders of initiating or maintaining sleep,sleep-wake transition disorders and excessive sleep sweating between two groups(P<0.01).There were significant differences in the night sleep monitoring parameters between two groups(P<0.05).Full scale response control quotient(FSCQ)and full scale attention quotient(FSAQ)in asthma non-control group detected by IVA-CPT were significantly lower than those in basic control group(P<0.01).Among the D-N:CAS parameters,there were significant differences in planning ability(PLAN),simultaneous processing ability(SIM),attention ability(ATT),successive processing ability(SUC)and full cognition score(FS)of children between two groups(P<0.05).FSCQ and FSAQ in IVA-CPT parameters and PLAN,SIM,ATT,SUC and FS in D-N:CAS parameters were negatively correlated with SDSC total score,disorders of initiating or maintaining sleep,sleep-wake transition disorders and AHI in the sleep parameters(all P<0.05),and positively correlated with sleep efficiency and lowest blood oxygen value(all P<0.05).Conclusion Children with asthma are prone to sleep structure disorder and attention deficit hyperactivity disorder,which are related to each other.

关 键 词：哮喘 睡眠障碍 注意力缺陷障碍伴多动 儿童 

分 类 号：R25.63[医药卫生—中医内科学]