血清CEA、SCCA、NSE联合多层螺旋CT在诊断周围型肺癌中的应用  

Application of Serum CEA, SCCA and NSE Combined with Multi-slice Spiral CT in the Diagnosis of Peripheral Lung Cancer

作　　者：李鹏飞[1] 台娜 马小玉[1] 巫志勇[1] LI Peng-fei;TAI Na;MA Xiao-yu;WU Zhi-yong(Department of Respiratory,Hospital of Mentougou District,Beijing 102300,China)

机构地区：[1]北京市门头沟区医院呼吸科,北京102300

出　　处：《中国CT和MRI杂志》2020年第7期42-44,154,共4页Chinese Journal of CT and MRI

摘　　要：目的探讨血清癌胚抗原(CEA)、鳞状细胞癌相关抗原(SCCA)、神经元特异性烯醇化酶(NSE)联合多层螺旋CT(MSCT)对周围型肺癌的诊断价值。方法回顾性分析我院收治的经手术病理检查确诊为周围型肺癌的105例患者临床资料,所有患者术前均进行血清CEA、SCCA、NSE检测及MSCT检查,以手术病理结果为标准,分析血清CEA、SCCA、NSE联合MSCT对周围型肺癌的诊断价值。结果 MSCT单检对周围型肺癌检测阳性率高于血清CEA、SCCA、NSE单检(P<0.05),血清CEA、SCCA、NSE及MSCT四项联检的周围型肺癌检查阳性率高于单检(P<0.05)。四项联检对肺腺癌、肺鳞癌、小细胞肺癌和未分化型周围型肺癌检测阳性率分别为93.75%、94.44%、84.62%和83.33%,对Ⅰ~Ⅱ期和Ⅲ~Ⅳ期周围型肺癌检测阳性率分别为87.76%和96.43%,对肿瘤直径<2cm、2~6cm和>6cm周围型肺癌检测阳性率分别为62.50%、84.51%和96.43%,均高于单独检测。结论血清CEA、SCCA、NSE及MSCT对周围型肺癌均有一定诊断价值,且四项联检可提高周围型肺癌阳性检出率。Objective To investigate the diagnostic value of serum carcinoembryonic antigen(CEA), squamous cell carcinoma associated antigen(SCCA), neuron specific enolase(NSE) combined with multi-slice spiral CT(MSCT) for peripheral lung cancer. Methods The clinical data of 105 patients with peripheral lung cancer diagnosed by surgical pathology in our hospital were retrospectively analyzed. All patients was detected by serum CEA, SCCA, NSE and MSCT before operation. Taking the surgical pathology results as the standard, the diagnostic value of serum CEA, SCCA, NSE combined with MSCT for peripheral lung cancer was analyzed. Results The positive rate of for peripheral lung cancer by MSCT single-detection was higher than that by serum CEA, SCCA and NSE single-detection(P<0.05). The positive rate for peripheral lung cancer by the combined detection of serum CEA, SCCA, NSE and MSCT was higher than single detection(P<0.05). The positive rates for lung adenocarcinoma, lung squamous cell carcinoma, small cell lung cancer and undifferentiated peripheral lung cancer by the combined detection of the four were 93.75%, 94.44%, 84.62% and 83.33%, respectively. The detection positive rates for lung cancer at Ⅰ to Ⅱ and Ⅲ to Ⅳ stage were 87.76% and 96.43%, respectively. The detection positive rates for lung cancer detection with tumor diameter less than 2 cm, tumor diameter 2 to 6 cm and tumor diameter greater than 6 cm were 62.50%, 84.51% and 96.43%, respectively, which were all higher than the single detection. Conclusion Serum CEA, SCCA, NSE and MSCT have certain diagnostic value for peripheral lung cancer, the four joint detection can improve the positive detection rate of peripheral lung cancer.

关 键 词：癌胚抗原 鳞状细胞癌相关抗原 神经元特异性烯醇化酶 多层螺旋CT 周围型肺癌 

分 类 号：R322.3[医药卫生—人体解剖和组织胚胎学]