Network analysis of primary active compounds in Danqi analogous formulas for treating cardiovascular disease  

作　　者：Shichao Zheng Yanling Zhang Yanjiang Qiao 

机构地区：[1]Research Center of Traditional Chinese Medicine Information Engineering,School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 100102,China

出　　处：《Journal of Traditional Chinese Medical Sciences》2016年第2期116-123,共8页中医科学杂志（英文）

基　　金：support of this work by the National Natural Science Foundation of China(No.81430094 and 81173522);the National Key Technology R&D Program(2008BAI51B01).

摘　　要：Objective:Used extensively to treat cardiovascular disease,Danqi analogous formulas(DQAF)include prescriptions for Danqi(DQ),Fufang Danshen(FFDS)and Qishen Yiqi(QSYQ).Differences in prescription compatibility result in varying emphases of DQAF in clinical application.Methods and results:Based on network analysis in this study,common and distinct mechanisms of DQAF actions on cardiovascular disease were analyzed at a systemic level.Components etargetsepathways models were developed by Cytoscape(http://www.cytoscape.org/);whereby,target information for active compounds was obtained based on the PharmMapper database(http://59.78.96.61/pharmmapper/),which was further used to search pathways using the Kyoto Encyclopedia of Genes and Genomes database(http://www.genome.jp/kegg/).Based on target and network analyses,we discovered RBP4 is a potential common target of DQAF,while mitogen-activated protein kinase 1(MAPK1)and glutathione S-transferase P were potential targets of FFDS and QSYQ,respectively.Furthermore,the potential of DQAF to treat cardiovascular disease occurs through effects on the endocrine,immune,and digestive systems,in addition to lipid,sugar and amino acid metabolic pathways.Whereas FFDS exhibits effects on Toll-like receptor,transforming growth factor beta and MAPK signaling pathways;QSYQ exerts effects on cyclic adenosine monophosphate signaling,as well as metabolism of glutathione and arachidonic acid.

关 键 词：NETWORK Danqi analogous formulas DOCKING Cardiovascular diseases 

分 类 号：R284.1[医药卫生—中药学]