生物聚氨酯/羟基磷灰石微相分离与形状记忆性能  

Micro-Phase Separation Structure and Shape Memory Properties of Bio-Polyurethane/Hydroxyapatite

作　　者：张培[1] 刘浩[1] 王玉杰[1] 何素芹[1,2] 黄淼铭 刘文涛 朱诚身[1] Pei Zhang;Hao Liul;Yujie Wang;Suqin He;Miaoming Huang;Wentao Liu;Chengshen Zhu(School of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450001,China;Henan Key Laboratory of Advanced Nylon Materials and Application,Zheng zhou University,Zhengzhou 450001,China)

机构地区：[1]郑州大学材料科学与工程,河南郑州450001 [2]河南省先进尼龙材料及应用重点实验室,河南郑州450001

出　　处：《高分子材料科学与工程》2020年第4期119-127,共9页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(51703207)。

摘　　要：形状记忆功能化生物聚氨酯在医用植入体材料中备受关注,而聚氨酯的形状记忆性能与其微相分离结构密切相关。文中以可降解聚己内酯二醇(PCL-diol)、脂环形异佛尔酮二异氰酸酯(IPDI)、1,4-丁二醇(BDO)为单体通过两步法合成生物聚氨酯(PU),以溶液共混的方式加入PU基体中,制备了一系列聚氨酯/羟基磷灰石(PU/HA)复合材料。通过场发射扫描电子显微镜、傅里叶变换红外光谱、热失重分析和动态力学热分析等不同表征方法研究了HA的引入对PU基体微相分离的影响,及其与宏观形状记忆性能的关系,并考察了材料的生物安全性。结果表明,HA的引入明显促进了PU的微相分离,随着HA含量的增加,硬段与软段的玻璃化转变温度差值越大,表明微相分离程度越高。在HA质量分数低于15%时,HA的含量越高,形状回复越快,表明微相分离程度越高,形状记忆性能越好。L929细胞毒性测试结果显示,PU/HA具有良好的细胞安全性,在医用骨修复领域有潜在的应用价值。Shape memory functionalized bio-polyurethane has attracted much attention in medical implant materials,and the shape memory performance of polyurethane is closely related to its micro-phase separation structure.In this study,polyurethane(PU)was synthesized by two-step process using degradable polycaprolactone diol(PCL-diol),alicyclic isophorone diisocyanate(IPDI),and 1,4-butanediol(BDO)as monomer.And a series of polyurethane/hydroxyapatite(PU/HA)composites were thus prepared by solution blending.The effects of HA on the microphase separation structure of PU matrix and its relationship to macroscopic shape memory performance were studied by scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TG)and dynamic thermomechanical analysis(DMA).Moreover,the biosafety of the material was also examined by MTT cytotoxicity evaluation.Results show that the addition of HA significantly promotes the microphase separation of PU.The difference in the glass transition temperature between the hard segment and the soft segment increases as the increase of HA loading,which indicates the introduction of HA leads to a higher degree of microphase separation.Accordingly,the shape recovery performance increases as the increased loading of HA.The results of L929 cytotoxicity test show that PU/HA has good cell safety and potential application in the field of medical bone healing.

关 键 词：生物聚氨酯 羟基磷灰石 微相分离 形状记忆 骨修复 

分 类 号：TQ323.8[化学工程—合成树脂塑料工业]