Effect of co-existent components in CO2 supercritical fluid extract of Angelica Sinensis Radix on metabolism of Z-ligustilide after oral administration in rats  

作　　者：Bochen Zhao Qing Zhang Hongmei Lin Qingguo Ru Qian Kang Hui Li Yewen Zhang Qing Wu 

机构地区：[1]Beijing University of Chinese Medicine,Beijing 100029,China

出　　处：《Journal of Traditional Chinese Medical Sciences》2014年第2期126-134,共9页中医科学杂志（英文）

基　　金：by the National Natural Science Foundation(No.81073059).

摘　　要：Objective:To establish a basis for Angelica Sinensis Radix(ASR)as a dietary supplement for colorectal cancer chemoprevention,the effect of co-existent components in supercritical fluid extract(SFE)of ASR on the pharmacokinetics of Z-ligustilide after oral administration was investigated in vitro and in vivo.Methods:Incubation in gastrointestinal contents and incubation in rat liver tissue homogenates post-mitochondrial supernatant(PMS)experiments were used to study changes in the levels of Z-ligustilide in vitro.Results:Within 4 hours,the level of Z-ligustilide in SFE declined at a slower rate than in its pure form.Clearance of Z-ligustilide after administration in its pure form was significantly slower than that of SFE of ASR(CL,0.96±0.16 mL·min/kg versus 1.24±0.21 mL·min/kg P<0.05;AUC,243.37±16.84 versus 176.69±12.59 mg·min/L).Conclusion:These phenomena may be attributed to the interactions between the co-existent components in SFE of ASR and Z-ligustilide enhancing the stability of Z-ligustilide.These results suggest that the bioavailability of Z-ligustilide in SFE of ASR is improved.However,stabilization of plasma concentration was not sustained,so that the efficacy of active components could not be maintained.Thus,further processing of SFE of ASR is required.

关 键 词：Angelica Sinensis Radix Supercritical fluid extract Z-ligustilide METABOLISM 

分 类 号：R285.5[医药卫生—中药学]