Special interstitial route can transport nanoparticles to the brain bypassing the blood-brain barrier  

作　　者：Nan Hu Xiaoli Shi Qiang Zhang Wentao Liu Yuting Zhu Yuqing Wang Yi Hou Yinglu Ji Yupeng Cao Qian Zeng Zhuo Ao Quanmei Sun Xiaohan Zhou Xiaochun Wu Dong Han 

机构地区：[1]CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology Beijing 100190,China [2]School of Future Technology,University of Chinese Academy of Sciences,Bejjing 100049,China [3]Department of Traditional Chinese Medicine,Chengde Medical Uriversity,Chengde 066000,China [4]Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Nano Research》2019年第11期2760-2765,共6页纳米研究（英文版）

基　　金：the Chinese Academy of Sciences(No.ZDKYYQ20190002)。

摘　　要：Nowadays,nanoparticles(NPs)are considered to be ideal tools for bioimaging and drug delivery.Although increasing research has focused on NP biodistribution,transportation in the interstitial architecture has been neglected.The entire body is connected by the interstitial architecture,which can provide a long-range and direct pathway for NP biodistribution in a nonvascular system.In this study,we report that 10-nm gold NPs injected directly into the interstitial architecture of the tarsal tunnel of rats(intervaginal space injection(ISI))were delivered to the brain without crossing the blood-brain barrier.Furthermore,NaGdF4 nanoparticles were used to explore the transportation route by magnetic resonance imaging.The results demonstrated that,after ISI,the NaGdF4 nanoparticles were transported through the perivascular interstitial space of the carotid arteries and brain vessels to the brain.This is a special nonvascular transportation route like a stream based on the interstitial architecture that provides an alternative pathway for NP biodistribution.

关 键 词：NANOPARTICLES interstitial stream mass transportation blood-brain barrier magnetic resonance imaging 

分 类 号：O48[理学—固体物理]