新活素联合左西孟旦治疗慢性心力衰竭急性发作的疗效观察  

Observation on the Curative Effect of Levosimendan in the Treatment of Acute Attack of Chronic Heart Failure

作　　者：王春蕾 WANG Chun-lei(No.2 Department of Cardiology,The First Hospital of Dandong,Dandong 118000,China)

机构地区：[1]辽宁省丹东市第一医院心内一科,辽宁丹东118000

出　　处：《中国医药指南》2020年第15期112-113,共2页Guide of China Medicine

摘　　要：目的探讨新活素联合左西孟旦治疗慢性心力衰竭急性发作的疗效。方法将2017年7月至2018年7月96例慢性心力衰竭急性发作患者随机分为两组各48例,研究组采用新活素联合左西孟旦治疗,对照组单用新活素治疗,比较两组治疗前后的超声心动图、血浆氨基末端B型利钠肽前体(NT-proBNP)水平、血清炎性因子水平、治疗后6个月内的预后及不良反应。结果两组治疗后的左室射血分数(LVEF)、每搏输出量(SV)及血浆NT-proBNP水平均明显改善,且研究组改善情况明显优于对照组(P<0.05)。两组治疗后血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素石(IL-6)水平均明显降低,且研究组明显低于对照组(P<0.05)。研究组心力衰竭再次入院、心血管死亡的发生率比较无明显差异(P>0.05),复合终点的发生率明显低于对照组(P<0.05)。研究组总的不良反应发生率为8.3%,对照组为10.5%,两组比较无明显差异(P>0.05)。结论慢性心力衰竭急性发作采用新活素联合左西孟旦治疗,可有效改善心功能,降低血清炎性因子水,提高近期预后,具有显著的功效与安全性。Objective To investigate the curative effect of levosimendan combined with prozac in the treatment of acute attack of chronic heart failure.Methods 96 patients with acute attack of chronic heart failure from July 2017 to July 2018 were randomly divided into two groups,48 cases in each group.The study group were treated with neosporin combined with levosimendan,while the control group were treated with levosimendan alone.Echocardiography,plasma amino-terminal b-type natriuretic peptide precursor(nt-probnp)level,serum inflammatory factor level,prognosis and adverse reactions within 6 months after treatment were compared between the two groups before and after treatment.Results Left ventricular ejection fraction(LVEF),stroke output(SV)and plasma nt-probnp levels were significantly improved in both groups after treatment,and the improvement in the study group were significantly better than the control group(P<0.05).Serum levels of CRP,TNF-αand IL-6 in both groups were significantly decreased after treatment,and those in the study group were significantly lower than those in the control group(P<0.05).There were no significant difference in the incidence of heart failure readmission and cardiovascular death in the study group(P>0.05),and the incidence of composite endpoint were significantly lower than those in the control group(P<0.05).The overall incidence of adverse reactions of the study groupwas 8.3%,and that of the control group 10.5%,and there were no significant difference between the two groups(P>0.05).Conclusion Acute attack of chronic heart failure treated with neosporin combined with levosimendan can effectively improve heart function,reduce serum inflammatory factor water,improve short-term prognosis,with significant efficacy and safety.

关 键 词：新活素 左西孟旦 慢性心力衰竭急性发作 

分 类 号：R541.7[医药卫生—心血管疾病]