胃滞留给药系统的研究进展及其在中药制剂中的应用  

Research Progress of Gastroretentive Drug Delivery System and Its Application in Traditional Chinese Medicine

作　　者：张纯刚[1] 于子尧 于琛琛 程岚[1] 康廷国[1] ZHANG Chungang;YU Ziyao;YU Chenchen;CHENG Lan;KANG Tingguo(Liaoning University of Traditional Chinese Medicine,Dalian 116600,China)

机构地区：[1]辽宁中医药大学,辽宁大连116600

出　　处：《中国现代应用药学》2020年第7期877-885,共9页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(81503257);国家重点研发计划(2018YFC1706903);辽宁省博士启动基金(201501098)。

摘　　要：在口服制剂中,胃滞留给药系统可以延长药物在胃内的滞留时间,进而延长其在整个胃肠道的转运时间,增加药物的吸收,从而提高临床疗效,因此它是一种理想的给药系统。本文通过查阅国内外文献进行归纳,从胃滞留给药系统的影响因素、分类、制剂研究(包括中药胃滞留制剂)及上市产品进展等方面对近年来胃滞留制剂的研究进展进行综述。Gastroretentive drug delivery systems which are ideal oral drug delivery systems can increase the gastric residence time and whole gastrointestinal transit time.They also can improve the absorption and clinical efficacy,so they are ideal drug delivery system.Therefore,the introduction of the progress of the novel gastroretentive drug delivery system was presented through literature review at home and abroad.The influence factors,classification and progress of related products of gastroretentive drug delivery systems(including gastric retenting drug delivery system for Chinese medicine)are summarized.

关 键 词：胃滞留系统 胃滞留时间 中药 评价 

分 类 号：R94[医药卫生—药剂学]