肝型脂肪酸结合蛋白与相关疾病的研究  

Study on Liver-type Fatty Acid Binding Proteins and Related Diseases

作　　者：王可欣 马心迪 刘剑[1] 许星柱 徐敬芳 陈炜 苏素文[4] WANG Ke-xin;MA Xin-di;LIU Jian;XU Xing-zhu;XU Jing-fang;CHEN Wei;SU Su-wen(Department of Pharmacy,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China;The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei,China;Department of Pharmacy,Shijiazhuang Third Hospital,Shijiazhuang 050000,Hebei,China;Department of Pharmacology,Hebei Medical University,Shijiazhuang 050017,Hebei,China)

机构地区：[1]河北医科大学第二医院药学部,河北石家庄050000 [2]河北医科大学第四医院,河北石家庄050011 [3]石家庄市第三医院药剂科,河北石家庄050000 [4]河北医科大学药理学教研室,河北石家庄050017

出　　处：《医学信息》2020年第10期23-26,共4页Journal of Medical Information

基　　金：国家自然科学基金(编号:81773828);河北省自然科学基金(编号:H2018206297、C2011206145)。

摘　　要：肝型脂肪酸结合蛋白(FABP1)属于脂肪酸结合蛋白(FABPs)家族的成员之一,是肝脏中唯一表达可结合长链脂肪酸的胞质蛋白,在脂肪酸的吸收、转运等过程中发挥重要作用。近年研究表明FABP1表达异常与脂代谢异常相关疾病密切相关,同时其表达异常与肾脏疾病、药物性肝损伤及恶性肿瘤等亦有一定的关系。本文主要对FABP1的结构、功能及其和肝脏疾病、肾脏疾病、糖尿病及肿瘤的关系进行综述,旨在为临床相关疾病的防治提供新的治疗靶点和治疗策略。Liver-type fatty acid binding protein(FABP1) is a member of the family of fatty acid binding proteins(FABPs), it is the only cytoplasmic protein in the liver that can bind long-chain fatty acids and plays an important role in fatty acid absorption and transport. Recent studies have shown that abnormal expression of FABP1 is closely related to diseases related to abnormal lipid metabolism, and that abnormal expression is also related to kidney disease, drug-induced liver injury and malignant tumors. This article mainly reviews the structure and function of FABP1 and its relationship with liver disease, kidney disease, diabetes and tumor, and aims to provide new therapeutic targets and treatment strategies for the prevention and treatment of clinically related diseases.

关 键 词：肝型脂肪酸结合蛋白 肝损伤 恶性肿瘤 肾脏疾病 糖尿病 

分 类 号：Q591.5[生物学—生物化学]