右美托咪定联合丙泊酚对无抽搐电休克治疗精神病患者肌肉痛程度的影响  

Dexmedetomidine Combined with Propofol on Patients with Muscle Pain Treated by Non-Convulsive Electroconvulsive Therapy

作　　者：高彦花[1] 姚晔显 张楠 孙浩 GAO Yanhua;YAO Yexian;ZHANG Nan;SUN Hao(Department of Anesthesiology,Shijiazhuang Eighth Hospital,Shijiazhuang,Heibei,China 050000)

机构地区：[1]河北省石家庄市第八医院麻醉科,河北石家庄050000

出　　处：《中国药业》2020年第10期151-153,共3页China Pharmaceuticals

基　　金：河北省医学科学研究重点课题[20181081]。

摘　　要：目的探讨无抽搐电休克治疗前给予右美托咪定联合丙泊酚对精神病患者术后肌肉痛程度及血流动力学的影响。方法选取医院2017年3月至2019年3月以无抽搐电休克治疗的精神病患者102例,按随机数字表法分为对照组和联合组,各51例。两组患者在进行无抽搐电休克治疗前均给予丙泊酚静脉注射,联合组患者加用右美托咪定静脉泵注。结果联合组患者术后肌肉疼痛率为64.71%,显著低于对照组的94.12%(P<0.05);联合组患者在麻醉给药10 min(T1)和电击5 min(T2)后的心率(HR)和平均动脉压(MAP)水平显著低于对照组(P<0.05);两组患者术后苏醒时间、自主呼吸恢复时间及能量抑制指数比较无显著差异(P>0.05);联合组不良反应发生率为5.88%,显著低于对照组的27.45%(P<0.05)。结论在无抽搐电休克治疗精神病前加用右美托咪定联合丙泊酚,能显著缓解患者的术后肌肉痛程度,稳定血流动力学指标。Objective To investigate the effect of dexmedetomidine combined with propofol on patients with muscle pain treated by non-convulsive electroconvulsive therapy.Methods A total of 102 psychiatric patients treated with electroconvulsive therapy from March 2017 to March 2019 were selected and divided into the control group and combined group by random number table method,51 cases in each group.Both groups were given propofol injection,while on this basis,the combined group were given dexmedetomidine intervention.Results The postoperative muscle pain rate of the combined group was 64.71%,which was significantly lower than 94.12%of the control group(P<0.05).The levels of SPO2 at anesthesia administration 10 min(T1)and electroconvulsive therapy 5 min(T2)in the combined group were significantly lower than those of the control group(P>0.05).There was no significant difference in recovery time,spontaneous breathing recovery time and energy inhibition index between the two groups(P>0.05).The adverse reaction rate of the combined group was 5.88%,which was significantly lower than 27.45%of the control group(P<0.05).Conclusion The combination of dexmedetomidine and propofol before electroconvulsive therapy for psychiatric patients can significantly relieve pain and stabilize hemodynamics.

关 键 词：右美托咪定 丙泊酚 无抽搐电休克 肌肉痛 血流动力学 

分 类 号：R969.4[医药卫生—药理学] R971.4[医药卫生—药学]