结合SPT技术的TransPRK与传统TransPRK手术术后早期视力及屈光结果对比研究  

Transepithelial Photorefractive Keratectomy with or without Assistance of Smartpulse Technology

作　　者：黄履晟 张日平[1] 孙丽霞[1] 李瑾瑜[1] HUANG Lvsheng;ZHANG Riping;SUN Lixia;LI Jinyu(Joint Shantou International Eye Center of Shantou University and Chinese University of Hong Kong,Shantou 515041,Guangdong,China)

机构地区：[1]汕头大学·香港中文大学联合汕头国际眼科中心,广东汕头515041

出　　处：《汕头大学学报（自然科学版）》2020年第2期73-80,共8页Journal of Shantou University：Natural Science Edition

摘　　要：通过对比结合智能脉冲技术(Smartpulse Technology)的经上皮准分子激光角膜切削术(Transepithelial photorefractive keratectomy)(SPT-TransPRK)和传统经上皮准分子激光角膜切削术(TransPRK)治疗近视散光患者术后裸眼视力、最佳矫正视力、等效球镜度以及术后角膜上皮下混浊(Haze)情况,从而对两种术式疗效进行评估.采用回顾性非随机对照研究,收集2014年8月至2017年6月在汕头国际眼科中心行结合SPT技术的TransPRK手术患者及传统TransPRK手术患者.纳入行结合SPT技术的TransPRK手术患者22人44眼为SPT-TransPRK组,纳入行传统TransPRK手术患者26人52眼为TransPRK组,收集术后5天,2周,1月,3月裸眼视力、最佳矫正视力、等效屈光度以及术后1月、3月角膜上皮下混浊(Haze)情况.裸眼视力、最佳矫正视力、等效屈光度、角膜上皮下混浊(Haze)情况.结果显示术后第5天,SPT-TransPRK组裸眼视力(Uncorrected visual acuity,UCVA)为0.15±0.13,TransPRK组裸眼视力(UCVA)为0.25±0.21,两组之间差异有统计学意义(p=0.004). SPT-TransPRK组UCVA在0.6以上者占82%,TransPRK组占50%,差异有统计学意义(p=0.01);SPT-TransPRK组UCVA在0.8以上者占68%,TransPRK组占37%,两组之间差异有统计学意义(p=0.03).两组等效球镜度(Spherical equivalent,SE)及最佳矫正视力(Best corrected visual acuity,BCVA)之间差异无统计学意义(p=0.62,p=0.39).术后2周,SPT-TransPRK组UCVA为0.01±0.06,TransPRK组UCVA为0.06±0.11,两组之间差异有统计学意义(p=0.01). SPT-TransPRK组UCVA在1.0以上为70%,TransPRK组为44%,差异有统计学意义(p=0.01).术后2周两组SE及BCVA之间的差异无统计学意义(p=0.85,p=0.08).术后1月及3月,两组在UCVA、SE、BCVA上的差异均无统计学意义.术后1、3个月两组Haze的分布未见统计学意义(p=0.14,p=0.08).结合智能脉冲技术(Smartpulse Technology)经上皮准分子激光角膜切削术(SPT-TransPRK)治疗近视散光患者较传统经上皮准分子激光角膜切削To evaluate visual recovery, the stage of haze after TransPRK with or without SPT during the early post-operative period. All patients underwent surgery in Joint Shantou International Eye Center of Shantou University and Chinese University from August 2014 to June 2017. 44 eyes of 22 patients underwent SPT-TransPRK as SPT-TransPRK group. Another 52 eyes of 26 patients underwent conventional TransPRK as TransPRK group. All patients took measurements of refractive power at 5 thday, 2 ndweek, 1 stmonth, 3 rdmonth post-operatively and slit-lamp microscopy to evaluate the stage of Haze at 1 stmonth, 3 rdmonth post-operatively.Uncorrected visual acuity, Best corrected visual acuity, Spherical equivalent, stage of Haze Visual acuity in post-operation: At 5 thday post-operatively the Uncorrected visual acuity(UCVA)of SPT-TransPRK group was0.15 ±0.13 while 0.25 ±0.21 in TransPRK group. There was statistical significance between the two groups(p =0.004). The ratio of UCVA ≥0.6 and ≥0.8 in SPT-TransPRK was 82%, 68% while 50%, 37% in TransPRK group. There was statistical significance between the two groups(p=0.01, p=0.03). At 2 nd week the UCVA of SPT-TransPRK group was 0.01±0.06 while 0.06±0.11 in TransPRK group. The ratio of UCVA≥1.0 in SPT-TransPRK was 70% while 44% in TransPRK group. There was statistical significance between the two groups(p=0.01). There was no statistic significance in the spherical equivalent(SE)and best corrected visual acuity(BCVA)at the 5 th day and 2 nd week post-operatively. For the UCVA, SE, BCVA at 1 st month and 3 rd month post-operatively, the differences were no statistic significance. There was no statistic significance in the Haze grade distribution of the two groups at 1 stmonth, 3 rdmonth post-operatively(p=0.14, p=0.08). Patients of SPT-TransPRK can receive better visual acuity as compared to the conventional TransPRK.

关 键 词：智能脉冲技术 经上皮准分子激光角膜切削术 角膜上皮下混浊 

分 类 号：R318.51[医药卫生—生物医学工程]