伊伐布雷定与美托洛尔治疗慢性心力衰竭伴心动过速的效果比较  

Comparison of the effects of ivabradine and metoprolol in the treatment of chronic heart failure with sychnosphygmia

作　　者：赵强[1] 汤利荣[1] 何旭[1] ZHAO Qiang;TANG Li-rong;HE Xu(Pharmacy Department,Hanzhong Central Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市中心医院药剂科,陕西汉中723000

出　　处：《临床医学研究与实践》2020年第16期53-55,共3页Clinical Research and Practice

摘　　要：目的比较伊伐布雷定与美托洛尔治疗慢性心力衰竭伴心动过速的效果。方法回顾性分析2017年1月至2019年10月我院收治的117例慢性心力衰竭伴心动过速患者的临床资料,所有患者使用利尿药、ACEI、正性肌力药及心肌代谢改善药物常规治疗基础上,分别加用伊伐布雷定(伊伐布雷定组,55例)和美托洛尔(美托洛尔组,62例)。比较两组患者的治疗效果、治疗前、后的心功能指标(LVESD、LVEDD、LVEF)、心率以及血清脑钠肽(BNP)水平。结果伊伐布雷定组的治疗总有效率显著高于美托洛尔组,差异具有统计学意义(P<0.05)。治疗后,两组患者的LVEDD、LVESD均减小,LVEF均提高,差异具有统计学意义(P<0.05)。治疗后,两组患者的心率均降低,且伊伐布雷定组低于美托洛尔组,差异具有统计学意义(P<0.05)。治疗后,两组患者的血清BNP水平均下降,且伊伐布雷定组低于美托洛尔组,差异具有统计学意义(P<0.05)。结论伊伐布雷定用于慢性心力衰竭伴心动过速的治疗中,可以有效改善心功能,且效果优于美托洛尔。Objective To compare the effects of ivabradine and metoprolol in the treatment of chronic heart failure with sychnosphygmia.Methods The clinical data of 117 patients with chronic heart failure and sychnosphygmia from January 2017 to October 2019 were retrospectively analyzed.On the basis of routine treatment with diuretics,ACEI,positive inotropic drugs and myocardial metabolism improving drugs,the patients were treated with ivabradine(55 cases,ivabradine group)and metoprolol(62 cases,metoprolol group),respectively.The therapeutic effects,cardiac function indexes(LVESD,LVEDD,LVEF),heart rate and serum brain natriuretic peptide(BNP)levels of patients in the two groups before and after treatment were compared.Results The total effective rate of treatment of the ivabradine group was significantly higher than that of the metoprolol group,and the difference was statistically significant(P<0.05).After treatment,LVEDD and LVESD in both groups decreased,while LVEF increased,the differences were statistically significant(P<0.05).After treatment,the heart rate in both groups decreased,and that in the ivabradine group was lower than the metoprolol group,the differences were statistically significant(P<0.05).After treatment,the level of serum BNP in both groups decreased,and that in the ivabradine group was lower than the metoprolol group,the differences were statistically significant(P<0.05).Conclusion In the treatment of chronic heart failure associated with sychnosphygmia,ivarabeldine can effectively improve cardiac function,and its effect is better than metoprolol.

关 键 词：伊伐布雷定 美托洛尔 慢性心力衰竭 心动过速 

分 类 号：R541.6[医药卫生—心血管疾病]