Excipient-free porphyrin/SN-38 based nanotheranostics for drug delivery and cell imaging  

作　　者：Ye Yuan Ruonan Bo Di Jing Zhao Ma Zhongling Wang Tzu-yin Lin Lijie Dong Xiangdong Xue Yuanpei Li 

机构地区：[1]Center for Smart Materials and Devices,State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology,Wuhan 430070,China [2]Department of Biochemistry and Molecular Medicine,UC Davis Comprehensive Cancer Center,University of California Davis,Sacramento 95817,USA [3]School of Veterinary Medicine,Yangzhou University,Yangzhou 225009,Chino [4]Department of Oncolog),Xiangya Hospital,Central South University,Changsha 410008,China [5]Department of Radiology,Shanghai General Hospital,Shanghai jiao Tong University School of Medicine,Shanghai 200080,China [6]Division of Hematology/Oncology,Department of Internal Medicine,University of California Davis,Sacramento 95817,USA [7]College of Life Sciences,Northwest University,Xian 710069,China

出　　处：《Nano Research》2020年第2期503-510,共8页纳米研究（英文版）

基　　金：The authors gratefully acknowledge the support from Dr.Lis faculty startup funds at UC Davis and Dr.Xues National Natural Science Foundation of China(NSFC)(No.81803002).

摘　　要：Nanotheranostics with comprehensive diagnostic and therapeutic capabilities show exciting cancer treatment potentials.Here,we develop an excipient-free drug delivery system for cancer diagnosis as well as therapy,in which a near infra-red photosensitizer and a chemotherapeutic drug can be self-delivered without any carriers.The building block of the drug delivery system was synthesized by covalently conjugating four anticancer drugs(7-ethyl-10-hydroxy-camptothecin,SN-38)with a photosensitizer(porphyrin)via hydrolyzable ester linkage,which endows the drug delivery system with 100%active pharmaceutical ingredients,excellent imaging,and therapeutic functionalities.The conjugates can readily self-assemble into nanosheets(PS NSs)and remain stable for at least 20 days in aqueous solution.In PS NSs,fluorescence resonance energy transfer(FRET)dominates the fluorescence of SN-38 and enables to monitor the drug release fluorescentiy.The PS NSs also show excellent anticancer activity in vitro,due to the increased cell uptake with the synergistic effect of photodynamic therapy and chemotherapy.

关 键 词：PORPHYRIN 7-ethyl-10-hydroxy-camptothecin(SN-38) drug delivery self-indication nanotheranostics photodynamic therapy 

分 类 号：O62[理学—有机化学]