高效液相色谱法测定苯胺法合成2-巯基苯并噻唑的萃取液  

Determination of Composition of Rosa Centifolia from Aniline Process Adopted to the Synthesis of 2-Mercaptobenzothiazole by High Performance Liquid Chromatography

作　　者：成兰兴 赵增兵 刘菲 邵国斌 张圆春 高青环 岳艳荣 Cheng Lanxing;Zhao Zengbing;Liu Fei;Shao Guobin;Zhang Yuanchun;Gao Qinghuan;Yue Yanrong(Henan Chemical Industry Research Institule Company Limited,Zhengzhou,Henan 450052,China)

机构地区：[1]河南省化工研究所有限责任公司,河南郑州450052

出　　处：《化学世界》2020年第5期350-354,共5页Chemical World

基　　金：河南省科技计划(No.182102311090);河南省科学院助推科技成果转化专项(Nos.18ZT08008、190208009)资助项目。

摘　　要：建立了一种同时定量测定苯胺法合成2-巯基苯并噻唑的萃取液中苯并噻唑、甲苯和2-巯基苯并噻唑的高效液相色谱分析方法.用C18柱分离,以V(乙腈)∶V(0.1 mol/L磷酸二氢钠)=60∶40为流动相,在波长254 nm处进行测定,分离效果较好,对方法的线性,精密度,加标回收率进行了考察,该方法线性关系良好,重现性好,相对标准偏差(RSD)小于0.05%,加标回收率为99.8%-100.3%.A method was presented for the simultaneous determination of benzothiazole,toluene and 2-mercaptobenzothiazole in rosa centifolia from the aniline process adopted to the synthesis of 2-mercaptobenzothiazole by high performance liquid chromatography(HPLC).C18 chromatographic column was used as stationary phase,and a mixture of acetonitrile 0.1 mol/L NaH2 PO4(60∶40,V∶V)was used as mobile phase.A good separation effect was obtained with a detection wavelength of 254 nm.This method showed good linearity and reproducibility.The relative standard deviation(RSD)was below 0.05%and the recovery of spiked sample was 99.8%~100.3%.

关 键 词：高效液相色谱 2-巯基苯并噻唑 苯并噻唑 甲苯 

分 类 号：O641.4[理学—物理化学]