基于网络药理学探讨南续益母片治疗类风湿关节炎的分子机制  

Study on Molecular Mechanism of Nanxu Yimu Tablet in Treatment of Rheumatoid Arthritis Based on Network Pharmacology

作　　者：韩隆胤 王强[1] 钱凯 杜彦仪 黄文广 郑乐 刘丹凯 丁文聪 郑雪霞[1] 林昌松[2] HAN Longyin;WANG Qiang;QIAN Kai;DU Yanyi;HUANG Wenguang;ZHENG Le;LIU Dankai;DING Wencong;ZHENG Xuexia;LIN Changsong(Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《中华中医药学刊》2020年第4期149-152,I0029,I0030,共6页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81573930,81774262);广东省自然科学基金(2017A030311009)。

摘　　要：目的基于网络药理学研究探讨南续益母片治疗类风湿关节炎的分子机制。方法使用TCMSP和TCMID数据平台筛选南续益母片的有效成分及靶点,通过TTD和DRUGBANK及DisGeNET数据库检索类风湿关节炎的疾病靶点,使用Bioinformatics&Evolutionary Genomics软件筛选关键靶点,运用ClueGO插件和EHBIO生物信息软件进行KEGG通路富集分析,使用STRING软件平台和Cytoscape软件构建成分-靶点-通路和蛋白互作网络。结果最终筛选出南续益母片有效成分13个,预测治疗靶点228个,作用于类风湿关节炎的重要靶点51个,通路富集分析显示南续益母片主要作用在与类风湿关节炎相关的炎症、免疫及细胞凋亡等信号通路。结论南续益母片具有多成分、多靶点的作用特点,通过影响炎症、免疫、细胞凋亡等方面发挥治疗类风湿关节炎的作用。Objective To investigate the molecular mechanism of Nanxu Yimu Tablet in the treatment of rheumatoid arthritis based on network pharmacology. Methods The TCMSP and TCMID data platforms were used to screen the active components and targets of Nanxu Yimu Tablet. The targets of rheumatoid arthritis were searched by TTD and DRUGBANK and DisGeNET databases, and key targets were screened using Bioinformatics & Evolutionary Genomics software. The ClueGO plug-in and EHBIO bioinformatics software performed KEGG pathway enrichment analysis, using the STRING software platform and Cytoscape software to construct a component-target-pathway and protein interaction network. Results Finally, 13 active components of Nanxu Yimu Tablet were screened, and 228 therapeutic targets were predicted. A total of 51 important targets for rheumatoid arthritis were analyzed. Pathway enrichment analysis showed that Nanxu Yimu Tablet acted on rheumatoid joints. Pathway enrichment analysis showed that Nanxu Yimu Tablet mainly acted on signaling pathways related to rheumatoid arthritis, such as inflammation, immunity and apoptosis. Conclusion Nanxu Yimu Tablet has the multi-component and multi-target characteristics, and plays a role in the treatment of rheumatoid arthritis by affecting inflammation, immunity and apoptosis.

关 键 词：南续益母片 类风湿关节炎 网络药理学 分子机制 信号通路 

分 类 号：R285[医药卫生—中药学]