共聚焦显微镜在常见结缔组织病中的图像特征分析  

Image Features of Connective Tissue Diseases Using Confocal Laser Scanning Microscope

作　　者：师小萌[1] 邢倩[1] 李领娥 张金芳[1] 白艳秋[1] 张立欣[1] 边莉[1] 陈潍[1] 吕培 李佩赛 SHI Xiaomeng;XING Qian;LI Ling'e;ZHANG Jinfang;BAI Yanqiu;ZHANG Lixin;BIAN Li;CHEN Wei;LYU Pei;LI Peisai(Department of Dermatology,Shijiazhuang Traditional Chinese Medicine Hospital,Shijiazhuang 050081,China)

机构地区：[1]石家庄市中医院皮肤科,河北石家庄050081

出　　处：《中国皮肤性病学杂志》2020年第6期644-649,共6页The Chinese Journal of Dermatovenereology

摘　　要：目的分析常见结缔组织病(CTD)的共聚焦显微镜(RCM)图像特征。方法回顾性分析32例常见CTD的RCM图像、组织病理资料,并进行对比分析。结果在RCM检查中,红斑狼疮(LE)、皮肌炎(DM)、硬化性苔藓均表现为界面皮炎,真皮浅层嗜色素细胞及色素颗粒,其中毛囊角栓、真皮浅层血管扩张充血在红斑狼疮及硬化性苔藓中常见。在硬皮病中浅层胶原折光略增强,在硬化性苔藓中胶原折光显著增强,走向僵硬或呈放射状排列,也可呈棉絮状,或境界模糊呈片状无结构影,失去原有纵横交错的排列方式。结论 RCM在常见CTD中的图像特征与组织病理改变颇为吻合,可以作为临床筛查CTD的有效无创检查方法,并可在治疗随访当中观察皮疹改善程度。Objective To analyze imaging features of common connective tissue diseases(CTD) using the rellectance confocal microscopy(RCM).Methods The RCM and histopathological data of 32 cases common CTD were retrospectively analyzed and compared.Results On RCM examination,lupus erythematosus(LE),dermatomyositis(DM) and lichen sclerosus were all manifested as interfacial dermatitis,superficial dermal pigmentophils and pigmentation granules,among which hair follicle keratosis and superficial dermal vasodilation and hyperemia were common in LE and lichen sclerosus.Superficial collagen refraction was increased slightly in scleroderma,and markedly increased in lichen sclerosus,which tended to be stiff or radial arranged,or in the shape of cotton flocculence,or blurred without structure,losing the original crisscross pattern.Conclusion The imaging features of RCM in common CTD are consistent with histopathological changes.Therefore,it can be used as an effective non-invasive method for clinical screening of CTD,and to observe the improvement of skin rash during treatment and follow-up.

关 键 词：结缔组织病 共聚焦显微镜(RCM) 组织病理 图像特征 分析 

分 类 号：R593.2[医药卫生—内科学]