兰州市区SO2、NO2浓度对荨麻疹日门诊人次的影响  

Effects of SO2 and NO2 Concentration on the Number of Daily Outpatient Visits for Urticaria in Lanzhou

作　　者：白瑶 石春蕊[2] 董继元[3] 光奇[4] 骆志成[5] 郗群[6] 何苑 BAI Yao;SHI Chunrui;DONG Jiyuan;GUANG Qi;LUO Zhicheng;XI Qun;HE Yuan(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Dermatology,the First Hospital of Lanzhou University,Lanzhou 730000,China;School of Public Health,Lanzhou University,Lanzhou 730000,China;Information Center,the First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Dermatology,Lanzhou University Second Hospital,Lanzhou 730000,China;Information Center,Lanzhou University Second Hospital,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院皮肤科,甘肃兰州730000 [3]兰州大学公共卫生学院,甘肃兰州730000 [4]兰州大学第一医院信息中心,甘肃兰州730000 [5]兰州大学第二医院皮肤科,甘肃兰州730000 [6]兰州大学第二医院信息中心,甘肃兰州730000

出　　处：《中国皮肤性病学杂志》2020年第6期704-710,共7页The Chinese Journal of Dermatovenereology

基　　金：甘肃省自然科学基金项目(18JR3RA337)。

摘　　要：目的探讨兰州市气态污染物(SO2、NO2)与荨麻疹门诊人次的相关性,以及冷暖季、性别和年龄分层后不同人群对NO2、SO2的敏感性。方法收集2013年1月18日-2017年12月31日荨麻疹患者的门诊记录,同期SO2、NO2浓度和气象资料。在控制长期趋势和星期几效应基础上,利用分布滞后非线型模型定量评估空气中SO2、NO2与荨麻疹日门诊就诊情况的暴露反应关系;并按照不同人群建立模型。结果研究期间,平均每日就诊荨麻疹患者(40.83±17.31)例;SO2、NO2平均浓度分别为24.14μg/m^3和43.69μg/m^3,经Spearman相关分析后发现荨麻疹日门诊人次与温度、相对湿度之间正相关,与SO2呈负相关;NO2与SO2两者之间为正相关。分析后发现SO2、NO2浓度变化和荨麻疹日门诊量之间呈正相关,NO2、SO2浓度每增加10μg/m^3,日门诊人次分别增加4.60%(95%CI:3.67%~5.53%)、3.15%(95%CI:1.84%~4.48%);经性别和年龄分层后,NO2、SO2浓度每增加10μg/m^3,男性荨麻疹患者分别增加4.74%(95%CI:3.58%~5.90%)、3.92%(95%CI:2.30%~5.57%),0~18岁人群荨麻疹患者分别增加5.55%(95%CI:4.25%~6.87%)、5.58%(95%CI:3.70%~7.48%);冷暖季分层后,冷季时NO2、SO2浓度每升高10μg/m3荨麻疹日门诊人次分别增加5.15%(95%CI:1.06%~3.81%)、2.87%(95%CI:1.11%~4.67%)。结论兰州地区SO2、NO2与荨麻疹日门诊人次之间呈正相关,各性别、年龄人群荨麻疹日门诊人次对SO2、NO2浓度变化的敏感程度也各不相同,且不同污染物在冷暖季对荨麻疹日门诊人次影响不同。Objective To determine the relationship between gaseous pollutants SO2 and NO2 and daily outpatient visits for urticaria,and the sensitivity of different seasons,gender,and age groups to SO2 and NO2 in Lanzhou,China.Methods Data of daily urticaria outpatient visits,concentrations of SO2 and NO2 and meteorological variables during the period from January 18,2013 to December 31,2017 were collected.A distributed lag nonlinear model(DLNM)was used to analyse the exposure-effect relationship between SO2,NO2 and daily outpatient visits for urticaria,based on the control of long-term trends and "day of-week" effects.At the same time,the model was established based on the different groups.Results During the study period,the average daily patient visits were 40.83±17.31.The average concentrations of SO2 and NO2 were 24.14 μg/m^3 and 43.69 μg/m^3,respectively.The Spearman′s correlations analysis showed that urticaria day outpatients′ visits were positively correlated with temperature and relative humidity,whereas they were negatively correlated with SO2. NO2 was positively correlated with SO2.The analysis showed that urticaria day outpatients′ visits were positively correlated with daily average SO2and NO2 concentrations,specifically,a 10 μg/m^3 increase of daily concentrations of NO2and SO2 was associated with 4.60%(95% CI:3.67 %~5.53%) and 3.15%(95% CI:1.84%~4.48%) increase in urticaria outpatient visits.Stratifying the patients according to gender and age,a 10 μg/m^3 increase of daily concentrations of NO2 and SO2 were associated with the percentage increase of 4.74%(95% CI:3.58 %~5.90%),3.92%(95% CI:2.30 %~5.57%) and 5.55%(95% CI:4.25%~6.87%),5.58%(95% CI:3.70%~7.48%) for male and below the age of 18 hospital outpatient visits,respectively.After the cool and warm seasons stratification,a 10 μg/m3 increase of daily concentrations of NO2 and SO2 was associated with 5.15%(95%CI:1.06%~3.81%) and 2.87%(95%CI:1.11%~4.67%) increase in urticaria outpatient visits in the cool period.Conclusion SO2 and NO2 are positiv

关 键 词：荨麻疹 空气污染 二氧化硫 二氧化氮 分布滞后非线型模型 门诊就诊人次 分析 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]