江西地区23例18岁以下儿童2019冠状病毒病临床分析  

Clinical features of coronavirus disease 2019 in children aged<18 years in Jiangxi,China:an analysis of 23 cases

作　　者：吴华平[1] 李兵飞 陈晓[3] 胡华著 江淑爱 程灏[6] 胡新和[7] 唐建新 钟福初[9] 曾令文 余伟[3] 袁妍 伍先飞 李育平 郑宗利 潘天波 吴志兴 袁金凤[15] 陈强[1] WU Hua-Ping;LI Bing-Fei;CHEN Xiao;HU Hua-Zhu;JIANG Shu-Ai;CHENG Hao;HU Xin-He;TANG Jian-Xin;ZHONG Fu-Chu;ZENG Ling-Wen;YU Wei;YUAN Yan;WU Xian-Fei;LI Yu-Ping;ZHENG Zong-Li;PAN Tian-Bo;WU Zhi-Xing;YUAN Jin-Feng;CHEN Qiang(Department of Pediatrics,Jiangxi Provincial Children′s Hospital/Children's Hospital,Nanchang University,Nanchang 330006,China)

机构地区：[1]江西省儿童医院/南昌大学附属儿童医院儿内科,江西南昌330006 [2]赣州市妇幼保健院儿科,江西赣州341000 [3]南昌大学第一附属医院儿科,江西南昌330006 [4]宜春市人民医院儿科,江西宜春336000 [5]上饶市人民医院儿科,江西上饶334000 [6]九江市妇幼保健院儿科,江西九江332000 [7]抚州市第一人民医院儿科,江西抚州344100 [8]萍乡市第三人民医院儿科,江西萍乡337000 [9]江西省胸科医院内科,江西南昌330006 [10]南康区第一人民医院儿科,江西赣州341400 [11]全南县人民医院儿科,江西赣州341800 [12]上饶市第二人民医院儿科,江西上饶334000 [13]鄱阳县人民医院儿科,江西上饶333100 [14]广丰区人民医院儿科,江西上饶334600 [15]丰城市人民医院儿科,江西宜春331100

出　　处：《中国当代儿科杂志》2020年第5期419-424,共6页Chinese Journal of Contemporary Pediatrics

摘　　要：目的研究18岁以下儿童2019冠状病毒病(COVID-19)的临床特征。方法回顾性分析江西地区2020年1月21日至2020年2月29日确诊的23例儿童COVID-19的临床资料(患儿年龄为3个月至17岁8个月)。结果23例COVID-19患儿中,17例为家庭聚集性发病;无症状感染3例(13%),轻型6例(26%),普通型14例(61%)。发热16例(70%),咳嗽11例(48%),发热伴咳嗽8例(35%),肺部湿啰音8例(35%)。从发病或首次新型冠状病毒SARS-CoV-2核酸阳性至核酸转阴时间为6~24 d(中位数12 d)。3例白细胞总数降低,2例淋巴细胞下降,2例C反应蛋白增高,2例D-二聚体增高。12例肺部CT异常,其中肺内片状磨玻璃影9例。23例均应用了抗病毒治疗,均治愈出院。结论18岁以下儿童COVID-19多为家庭聚集性发病,临床表现、实验室检查无特异性,症状较轻,预后较好。流行病学史在18岁以下儿童COVID-19诊断中非常重要。Objective To study the clinical features of coronavirus disease 2019(COVID-19)in children aged<18 years.Methods A retrospective analysis was performed from the medical data of 23 children,aged from 3 months to 17 years and 8 months,who were diagnosed with COVID-19 in Jiangxi,China from January 21 to February 29,2020.Results Of the 23 children with COVID-19,17 had family aggregation.Three children(13%)had asymptomatic infection,6(26%)had mild type,and 14(61%)had common type.Among these 23 children,16(70%)had fever,11(48%)had cough,8(35%)had fever and cough,and 8(35%)had wet rales in the lungs.The period from disease onset or the first nucleic acid-positive detection of SARS-CoV-2 to the virus nucleic acid negative conversion was 6-24 days(median 12 days).Of the 23 children,3 had a reduction in total leukocyte count,2 had a reduction in lymphocytes,2 had an increase in C-reactive protein,and 2 had an increase in D-dimer.Abnormal pulmonary CT findings were observed in 12 children,among whom 9 had patchy ground-glass opacities in both lungs.All 23 children received antiviral therapy and were recovered.Conclusions COVID-19 in children aged<18 years often occurs with family aggregation,with no specific clinical manifestation and laboratory examination results.Most of these children have mild symptoms and a good prognosis.Epidemiological history is of particular importance in the diagnosis of COVID-19 in children aged<18 years.

关 键 词：2019冠状病毒病 流行病学 临床特征 儿童 

分 类 号：R725.1[医药卫生—儿科]