系统性红斑狼疮患者贫血特点分析  

Analysis on the characteristics of anemia in patients with Systemic Lupus Erythematosus

作　　者：梅丽春 苏向珠 朱亭西 赵启波 翟建昭 武永康[1] MEI Lichun;SU Xiangzhu;ZHU Tingxi;ZHAO Qibo;ZHAI Jianzhao;WU Yongkang(Department of Laboratory Medicine,West China Hospital,S.C.U,Chengdu Sichuan 610041,China;Department of Clinical Laboratory,Zhaotong First People's Hospital;West China Biomedical Big Data Center,West China School of Medicine/West China Hospital,Sichuan University;Medical Big Data Center,Sichuan University)

机构地区：[1]四川大学华西医院实验医学科,四川成都610041 [2]昭通市第一人民医院检验科 [3]四川大学华西临床医学院/华西医院华西生物医学大数据中心 [4]四川大学医学大数据中心

出　　处：《中国输血杂志》2020年第3期230-233,共4页Chinese Journal of Blood Transfusion

基　　金：四川省成都市科技局课题(项目编号:2019-GH02-00006-HZ);四川大学华西医院学科卓越发展1·3·5工程项目(项目编号:ZYJC18042)。

摘　　要：目的调查分析系统性红斑狼疮(SLE)患者贫血的分布特点。方法收集华西医院2009年2月-2019年2月确诊SLE伴贫血的患者,分析SLE患者红细胞及相关指数以及贫血的类型和程度。结果SLE患者7074名,男936名,女6138名,男女之比1∶6.56,平均年龄(32.54±15.03)岁。SLE伴贫血患者2527名,占SLE患者的35.72%,平均年龄(37.14±14.21)岁,男242例占男性SLE患者的25.85%,女2285例占女性SLE患者的37.23%(两者比较χ2=45.75,P<0.05),男女之比为1∶9.44;其中极重度贫血占0.04%,重度贫血占3.68%,中度贫血占30.08%,轻度占66.20%;SLE贫血患者红细胞相关指数均值:RBC 3.44×1012/L,HGB 96 g/L,HCT 0.30 L/L,MCV 88.0fl,MCH 28.2 pg,MCHC 320.1g/L,RDW-CV 16.1%,RDW-SD 50.7fl。结论在调查范围内,SLE贫血患者约占SLE患者的三分之一,为正细胞正色素性贫血,以轻度贫血为主,女性SLE患者较男性更易发生贫血。SLE患者贫血的病因尚不完全清楚,对于慢性或原因不明的贫血患者应增加SLE相关抗体检测,及时评估贫血程度,需输血治疗的中重度贫血患者加强潜在疾病的筛查,可减少或避免输血反应的发生。Objective To investigate and analyze the distribution and characteristics of anemia in patients with systemic lupus erythematosus(SLE).Methods The patients diagnosed with SLE and anemia from February 2009 to February 2019 were collected in West China Hospital,and the red blood cells and related indexes of SLE patients were analyzed,as well as the type and degree of anemia.Results There were 7074 patients with SLE,with an average age of(32.54±15.03)years.There were 936 males and 6138 females.The male to female ratio was 1∶6.56.There were 2527 SLE patients with anemia,accounting for 35.72%of SLE patients,with an average age of(37.14±14.21)years.242 males accounted for 25.85%of male SLE patients,and 2285 females accounted for 37.23%of female SLE patients(χ2=45.75,P<0.05),the ratio of male to female was 1∶9.44.Among them,extremely severe anemia accounts for 0.04%,severe anemia accounts for 3.68%,moderate anemia accounts for 30.08%,and mild accounts for 66.20%;mean value of RBC index:RBC 3.44×1012/L,Hb 96 g/L,HCT 0.30 L/L,MCV 88.0 fl,MCH 28.2 pg,MCHC 320.1 g/L,RDW-CV 16.1%,RDW-SD 50.7 fl.Conclusion SLE anemia patients account for about one third of SLE patients.It is normocytic normochromic erythrocyte anemia,mainly mild anemia.Female SLE patients are more prone to develop anemia than men.The causes of anemia in SLE patients is not completely clear.SLE antibody testing and timely assess of anemia level should be added for patients with chronic or unexplained anemia;for patients with moderate to severe anemia requiring blood transfusion,screening for potential diseases can reduce or avoid the occurrence of blood transfusion reactions.

关 键 词：系统性红斑狼疮 贫血 血红蛋白 自身免疫性溶血性贫血 

分 类 号：R593.241[医药卫生—内科学] R556.61[医药卫生—临床医学]