老年慢性肺源性心脏病合并心力衰竭急性加重期患者血清NT-Pro-BNP和降钙素原水平及意义  

Changes of serum procalcitonin and NT-pro-BNP in elderly patients with chronic pulmonary heart disease and acute exacerbation of heart failure

作　　者：蔡秋妍 陈璟[1] CAI Qiuyan;CHEN Jing(Laboratory Department,Huaian Hospital of Traditional Chinese Medicine,Huaian Jiangsu 223001,China)

机构地区：[1]淮安市中医院检验科,江苏淮安223001

出　　处：《中国急救复苏与灾害医学杂志》2020年第5期519-522,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：淮安市科技局重点研发计划(社会发展)(编号:HAS201612)。

摘　　要：目的探究老年慢性肺源性心脏病合并心力衰竭急性加重期患者血清中N末端B型脑利钠肽前体(NT-pro-BNP)以及降钙素原的水平变化。方法收集淮安市中医院老年慢性肺源性心脏病合并心力衰竭急性加重期患者70例,于开始治疗前和治持3、7 d以及出院当天检测患者血清中降4弓素原和NT-pro-BNP水平变化,比较其与患者死亡的关系。结果存活组降钙素原和NT-pro-BNP在治疗第3天、第7天及出院当天均低于入院首日,差异有统计学意义(P<0.05);死亡组降钙素原和NT-pro-BNP在第3天、第7天及出院当天均高于入院首日,差异有统计学意义(P<0.05)。组间比较,入院时存活组血清NT-pro-BNP以及降钙素原与死亡组差异无统计学意义(P>0.05);与死亡组比较,存活组在治疗第3天、第7天及出院当天的降钙素原和NT-pro-BNP显著降低,差异有统计学意义(P<0.05)。结论入院后第3天和第7天的血清NT-pro-BNP和降钙素原水平与慢性肺心病心衰加重的病情有关,水平越高则病情越重,预后越差。Objective To investigate the changes of serum N-terminal B-type brain natriuretic peptide precursor(NT-pro-BNP)and procalcitonin in elderly patients with chronic pulmonary heart disease and acute exacerbation of heart failure.Methods Seventy patients with acute exacerbation of heart failure in elderly patients with chronic pulmonary heart disease were enrolled in our hospital.Serum procalcitonin and NT-pro-BNP levels were measured before treatment,3,7 days after treatment and on the day of discharge,and the relationship between procalcitonin and NT-pro-BNP levels and mortality was compared.Results The procalcitonin and NT-pro-BNP in survival group were lower than those on the first day of admission on the third day,the seventh day and the day of discharge,and the difference was statistically significant(P<0.05).The levels of procalcitonin and NT-pro-BNP in the death group were higher on the 3rd day,7th day and the first day of discharge than those on the first day of admission,and the difference was statistically significant(P<0.05).There was no significant difference in serum NT-pro-BNP and procalcitonin and death group between the two groups at the time of admission(P>0.05).Compared with the death group,the procalcitonin and NT-pro-BNP in the survival group decreased significantly on the 3rd day,7th day and the day of discharge,and the difference was statistically significan(P<0.05).Conclusion The serum NT-pro-BNP and procalcitonin levels on the 3rd and 7th day after admission were related to the aggravation of chronic pulmonary heart disease and heart failure.The higher the level,the worse the condition and the worse the prognosis.

关 键 词：肺源性心脏病 心力衰竭 降钙素原 N末端B型脑利钠肽前体 

分 类 号：R541.5[医药卫生—心血管疾病]