武汉市HIV/AIDS病人合并乙肝、丙肝感染情况分析  

Seroprevalence of hepatitis B virus(HBV)and hepatitis C virus(HCV)among HIV/AIDS patients in Wuhan

作　　者：刘薇 刘建忠[2] 阮连国 罗燕和 刘莉 张定宇 LIU Wei;LIU Jian-zhong;RUAN Lian-guo;LUO Yan-he;LIU Li;ZHANG Ding-yu(Wuhan Jinyintan Hospital,Wuhan,Hubei 430000,China;不详)

机构地区：[1]武汉市金银潭医院,湖北武汉430000 [2]湖北省中医院,湖北武汉430061

出　　处：《现代预防医学》2020年第10期1873-1875,1891,共4页Modern Preventive Medicine

基　　金：湖北省自然科学基金(2015CFA099)。

摘　　要：目的了解武汉市HIV/AIDS病人合并乙肝、丙肝感染情况及其相关因素。方法在2010-2018年武汉市报告的确证HIV/AIDS病人中,选取其一般人口学特征、感染途径、HBsAg、AntiHCV检测结果等信息进行整理分析,采用多元logistic回归分析合并感染相关因素。结果2010-2018年武汉市共报告HIV/AIDS病人5128人,男4630人(90.3%),女498人(9.7%)。年龄范围14~89岁,年龄中位数33(25~48)岁。其中,HBsAg阳性率为9.4%(443人),AntiHCV阳性率为3.3%(152人),合并HIV、HBV、HCV三重感染率为0.3%(12人)。在HIV/AIDS病人中,本省人群感染乙肝的可能性是本市人群的1.317倍,已婚/同居以及离异/分居/丧偶者感染乙肝的可能性分别是未婚者的2.044、1.892倍(P<0.05)。与2018年相比,2011-2013以及2015年报告的HIV/AIDS病人感染丙肝的可能性更高,经输血和静脉吸毒途径感染的HIV/AIDS病人感染丙肝的可能性分别是经性行为传播者的18.942倍、63.537倍(P<0.05)。结论武汉市HIV/AIDS病人合并乙肝、丙肝感染情况不容忽视,其感染乙肝、丙肝的相关因素并不相同,需积极进行评估。Objective To explore seroprevalence of hepatitis B virus(HBV)and hepatitis C virus(HCV)among HIV/AIDS patients in Wuhan city and its associated factors.Methods Demographics,route of HIV infection,HBsAg and AntiHCV status of HIV/AIDS patients in Wuhan city during 2010-2018 were selected and analyzed.We used multivariate logistic regression to explore the associated factors.Results Totally 5128 HIV/AIDS patients were reported in Wuhan city during 2010-2018,among which 4630 were males(90.3%)and 498 were females(9.7%).The age range was 14-89 years old,with a median age of 33(25-48)years.443(9.4%)were HIV-HBV co-infected,152(3.3%)were HIV-HCV co-infected and 12(0.3%)were HIV-HBV-HCV triple infection.Among HIV/AIDS patients,people who were living in Hubei province other than Wuhan city were more likely to infect HBV(OR=1.317,95%CI:1.002-1.732),married/lived together(OR=2.044)and divorced/separated/widowed(OR=1.892)ones were more likely to infect HBV compared with unmarried(P<0.05).Compared with 2018,HIV/AIDS patients reported in 2011-2013 and 2015 were more likely to infect HCV.HIV/AIDS patients infected by blood transfusion and injected drugs had higher risk of infecting HCV compared to those infected by sexual transmission(OR=18.942,95%CI:3.987-90.005;OR=63.537,95%CI:34.948-115.511;respectively).Conclusion Prevalence and coinfection of HBV and HCV among HIV/AIDS patients in Wuhan city cannot be ignored.The associated factors of HBV and HCV infection are different,and active assessment is in need.

关 键 词：HIV/AIDS病人 乙肝病毒 丙肝病毒 合并感染 

分 类 号：R181.3[医药卫生—流行病学]