C反应蛋白与冠心病痰瘀证候相关性研究Meta分析  

Meta-analysis on the Relationship between CRP and Phlegm and Blood Stasis Syndrome of Coronary Heart Disease

作　　者：张寒芳 王恒和[1] Zhang Hanfang;Wang Henghe(The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津中医药大学第一附属医院,天津300193

出　　处：《亚太传统医药》2020年第4期159-163,共5页Asia-Pacific Traditional Medicine

基　　金：国家自然科学基金面上项目(81573849)。

摘　　要：目的:探讨血清C反应蛋白(CRP)与冠心病痰瘀证候的相关性。方法:通过计算机检索中国知网、维普数据库、万方数据库、PubMed数据库中从2000年至2019年5月公开发表的文献,根据纳入标准筛选文献后应用NOS评价标准对纳入文献进行评分,采用Revman5.3软件进行Meta分析。结果:最终纳入9个研究,均为病例对照研究,共2231例研究对象,Meta分析结果显示痰浊证组血清CRP水平[WMD=5.67,95%CI(4.35,6.99)]、血瘀证组血清CRP水平[WMD=5.91,95%CI(4.53,7.29)]都明显高于正常对照组,差异有显著性(P<0.01);血瘀证组血清CRP水平高于痰浊证组[WMD=0.24,95%CI(0.03,0.44)],差异有显著性(P<0.05)。结论:血清CRP与冠心病痰瘀证候有密切的相关性,可作为冠心病痰瘀辨证的客观参考指标之一。然而,目前原始研究数目较少,研究质量偏低,加之中医辨证分型诊断标准尚不统一,故未来仍需进一步样本更大、质量更高的研究加以证实。Objective:To explore the relationship between CRP and phlegm and blood stasis syndrome of coronary heart disease(CHD).Methods:Searched published literature in China Knowledge Network,VIP Database,Wanfang Database and PubMed Database from 2000to May 2019through computer,after selecting the literature according to the inclusion criteria,used the NOS evaluation criteria to score the inclusion literature and then used Revman 5.3software for Meta-analysis.Results:Finally,9papers were collected,all of them were case-control studies,2231cases in total.Meta-analysis showed that serum CRP levels in the phlegm turbidity syndrome group[WMD=5.67,95%CI(4.35,6.99)]and in the blood stasis syndrome group[WMD=5.91,95%CI(4.53,7.29)]were obviously higher than those in the normal comparison group,the difference was significant(P<0.01);CRP levels in the blood stasis syndrome group were higher than those in the phlegm turbidity syndrome group[WMD=0.24,95%CI(0.03,0.44)],the difference was significant(P<0.05).Conclusion:CRP is closely related to phlegm and blood stasis syndrome of CHD,and can be used as one of the objective indicators of phlegm and blood stasis syndrome differentiation of CHD.However,the number of original research is small,the quality of research is low,and the diagnostic standards of TCM syndrome differentiation are not unified,so further research with larger samples and higher quality is still needed in the future.

关 键 词：冠心病 C反应蛋白(CRP) 痰浊证 血瘀证 META分析 

分 类 号：R256.22[医药卫生—中医内科学]