整合子与细菌耐药性的相关研究进展  

Progress in researches on bacterial integrons in antibiotic resistance

作　　者：刘秘 李万翔 李世荣[1] LIU Mi;LI Wanxiang;LI Shirong(Clinical Laboratory of Weifang People′s Hospital,Weifang,Shandong 261041,China)

机构地区：[1]潍坊市人民医院检验科,山东潍坊261041 [2]潍坊医学院医学检验学系,山东潍坊261053

出　　处：《中国微生态学杂志》2020年第4期465-468,共4页Chinese Journal of Microecology

基　　金：潍坊市卫生计生委科研项目计划(WFWSJS-2018-110)。

摘　　要：整合子是广泛存在于细菌中的一种可移动基因元件,它可以捕获外来基因盒并使其在细菌体内得到表达,在细菌耐药性的传播过程中扮演着重要角色。过去研究认为,细菌耐药是在质粒及转座子[1]等基因水平上广泛传播,近几年大量研究表明,细菌可通过位点特异性重组的方式将耐药基因盒捕获并整合到自身的染色体或者质粒DNA上,即细菌体内存在一种天然的基因克隆表达系统——整合子。细菌耐药的高频次出现已成为临床医疗工作中的瓶颈,整合子不仅在细菌耐药中起关键作用,而且在细菌适应性及基因进化中具有普遍又重要的意义。Integrons are mobile genetic elements in bacteria that allow efficient capture and expression of exogenous genes.They are widely known for their role in the dissemination of antibiotic resistance.Previous studies had suggested that bacterial drug resistance is widespread at the genetic level of plasmids and transposons.In recent years,a large number of studies have shown that bacteria can capture and integrate drugresistant gene boxes into their chromosomes or plasmid DNA through site-specific recombination,that is,bacteria have a natural gene cloning expression system-integron.The high frequency of bacterial drug resistance has become a choke point in clinical medical practice.Integrons not only play a key role in bacterial drug resistance,but also have a universal and important role in bacterial adaptability and gene evolution.

关 键 词：整合子 细菌耐药 基因盒 基因进化 

分 类 号：R446.5[医药卫生—诊断学]