血乳酸生物传感器在新冠肺炎诊疗中的应用探讨  

Application of blood lactic acid biosensor in the diagnosis and treatment of COVID-19

作　　者：孙慧囡 高广恒 刘庆艾 马耀宏 李静 史建国 SUN Hui-nan;GAO Guang-heng;LIU Qing-ai;MA Yao-hong;LI Jing;SHI Jian-guo(Shandong Provincial Key Laboratory of Biosensors, Biology Institute, Qilu University of Technology(Shandong Academy of Sciences) , Jinan 250103,China;Shandong Boke Biological Industry Co., Ltd., Jinan 250101,China)

机构地区：[1]齐鲁工业大学(山东省科学院)山东省科学院生物研究所,山东省生物传感器重点实验室,山东济南250103 [2]山东博科生物产业有限公司,山东济南250101

出　　处：《山东科学》2020年第3期1-6,共6页Shandong Science

基　　金：山东省重大科技创新工程项目(2018CXGC0608);山东省重点研发计划(2019GSF109017);山东省自然科学基金(ZR2019BC072);山东省科学院青年基金(2019QN002);山东省科学院院地产学研协同创新基金项目(2019-CXY15)。

摘　　要：新冠肺炎(COVID-19)疫情爆发已造成严重危害,对新冠肺炎进行快速诊断和实施精准治疗是目前面临的重大挑战。对近年来血乳酸指标在肺炎临床中的应用及血乳酸生物传感器方法学进行了回顾,提出血乳酸水平或血乳酸清除率是新冠肺炎病情分层、治疗效果评估和判断预后的重要指标。其中POCT(即时检验)血乳酸生物传感器快捷、经济、可靠,可实现临床患者或个人(家庭)血乳酸快速和连续的检测,有利于新冠肺炎病情严重度分层和治疗效果评估,也可使患者及时识别自身状况,解除心理顾虑,促进机体康复。The outbreak of COVID-19 has caused serious harm.The rapid diagnosis and precise treatment of COVID-19 are major challenges currently facing.In this paper,the clinical application of blood lactic acid index and blood lactic acid biosensors in recent years were reviewed.It is suggested that blood lactic acid level or blood lactate clearance is an important biochemical indicator for the severity stratification,evaluation of clinical therapeutic effect and prognosis of the disease.POCT blood lactic acid biosensor technology is fast,economical and realiable,which can realize the rapid and continuous diagnosis of blood lactic acid in clinical patients or indiciduals(family),and it is conducive to the severity stratification and evaluation of clinical therapeutic effect.It also helps patients identify their own condition in time,relieve psychological concerns,and promote physical recovery.

关 键 词：新冠肺炎 血乳酸 生物传感 POCT 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]