基因多态性与非创伤性股骨头坏死遗传易感性的研究进展  

Advances in research of gene polymorphisms in non-traumatic osteonecrosis of the femoral head

作　　者：安非梦 王建忠[2] An Feimeng;Wang Jianzhong(Inner Mongolia Medical University,Hohhot 010050,China;Department of Trauma,the Second Affliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China)

机构地区：[1]内蒙古医科大学,呼和浩特010050 [2]内蒙古医科大学第二附属医院创伤一科,呼和浩特010030

出　　处：《中华老年骨科与康复电子杂志》2020年第3期178-183,共6页Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition)

基　　金：国家自然科学基金(81160228,81260284,81660378)。

摘　　要：非创伤性股骨头坏死(NONFH)的发病与多种因素相关,如糖皮质激素、乙醇、减压病、镰刀细胞性贫血等,但无论是哪种病理过程最终均会导致骨细胞的死亡。近年来,随着分子遗传学的发展,利用分子生物学技术对基因与非创伤性股骨头坏死相关性进行病例对照研究,发现许多单核苷酸多态性(SNPs)位点与该病的发病密切相关。本文结合近期的遗传基因学研究,着重对非创伤性股骨头坏死发病相关的基因加以综述,并对其研究前景进行展望。Non-traumatic osteonecrosis of the femoral head(NONFH)is a disease with multiple aetiologies such as glucocorticoids,ethanol,decompression sickness and sickle cell anemia,with the death of osteocytes as the end stage of different pathological processes.Accompanied with the development of molecular genetics,a number of single nucleotide polymorphisms(SNPs)have been found to be closely related to the incidence of NONFH in case-control studies on the correlation between genes and NONFH by using molecular biology technologies.This article combined recent genetic studies to highlight the genetics of NONFH,and also discussed current problems and research prospect.

关 键 词：非创伤性股骨头坏死 发病机制 基因多态性 研究进展 

分 类 号：R681.8[医药卫生—骨科学]