基于网络药理学预测苎麻根治疗自然流产的作用机制  

Prediction mechanism of action of ramie root in the treatment of abortion based on network pharmacology

作　　者：赵彩霞 张芬芬 程梦迪 王荣 ZHAO Caixia;ZHANG Fenfen;CHENG Mengdi;WANG Rong(Anhui Key Laboratory of Embryo Development and Reproductive Regulation,Fuyang Normal University,Fuyang Anhui 236037,China)

机构地区：[1]阜阳师范大学胚胎发育与生殖调节安徽省重点实验室,安徽阜阳236037

出　　处：《阜阳师范大学学报（自然科学版）》2020年第2期40-45,共6页Journal of Fuyang Normal University:Natural Science

基　　金：安徽省自然基金面上项目(1908085mc85)资助。

摘　　要：为初步探究苎麻根治疗自然流产的药效成分及作用机制,本研究首先利用TCMSP及化学专业数据库等收集苎麻根的化学成分,并根据药代动力学参数筛选出苎麻根候选活性成分,然后进行苎麻根潜在蛋白靶点的预测;同时利用DiGSeE等搜索已报道的与自然流产相关的基因,将苎麻根相关基因靶点与流产相关基因靶点进行匹配,得到苎麻根活性成分治疗自然流产的潜在靶点,并对这些靶点进行通路的富集与分析,最后对苎麻根治疗自然流产的活性成分-蛋白靶点-信号通路网络进行可视化.研究初步预测苎麻根治疗自然流产的作用机制,为进一步研究苎麻根的保胎作用提供思路.In this study,in order to preliminary explore the medicinal ingredients and mechanism of ramie root in the treatment of natural abortion,the chemical constituents of ramie root were collected firstly by using TCMSP,chemical database,and so on.And the active ingredients of ramie root were selected according to pharmacokinetic parameters,subsequently predicted the potential protein targets of ramie root.At the same time,used DiGSeE and other searches for genes related to natural abortion,and matched the ramie root-related targets with abortion-related targets to obtain potential targets for ramie root active ingredients to treat abortion,the pathways were enriched and analyzed for these targets,finally the active components-targets-pathways network of ramie root was visualized.The research has preliminary predicted the mechanism of ramie root in the treatment of natural abortion,which provides clues for further in-depth study of ramie root's fetal preservation effect.

关 键 词：苎麻根 自然流产 网络药理学 

分 类 号：R285[医药卫生—中药学]