肾病综合征患者血清D-D水平及凝血四项的检测与临床意义  

Detection and Clinical Significance of Serum D-D Level and Four Items of Coagulation in Patients with Nephrotic Syndrome

作　　者：徐长青[1] XU Chang-qing(Department of Laboratory,Tieling Central Hospital,Tieling 112001,China)

机构地区：[1]铁岭市中心医院检验科,辽宁铁岭112001

出　　处：《中国医药指南》2020年第16期174-175,共2页Guide of China Medicine

摘　　要：目的探究肾病综合征患者血清D–二聚体(D-D)水平及凝血四项的检测与临床意义。方法回顾性选取2018年1月至2019年12月我院收治的92例肾病综合征患者进行研究,按照患者病情程度分组:A组共48例,处于肾功能代偿期;B组共44例,处于肾功能失代偿期,另选取同期在我院行体检的50名健康受检者设为C组,分析三组的D-D水平及凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)等凝血四项水平。结果A+B组的D-D水平及PT、APTT、TT检测水平均高于C组,FIB水平低于C组(P<0.05);A组的D-D水平及PT、APTT、TT检测水平均低于B组,FIB水平高于B组(P<0.05)。结论在肾病综合征患者中采用D-D水平及PT、APTT、TT、FIB等凝血四项检测,在检测患者的凝血状况及病情发展方面具有重要临床意义。Objective To explore the detection and clinical significance of serum D-dimer(D-D)level and four items of coagulation in patients with nephrotic syndrome.Methods A retrospective study was conducted on 92 cases of nephrotic syndrome in our hospital from January 2018 to December 2019.According to the degree of patients’condition,we divided them into four groups:48 cases in group A,in the period of renal function compensation;44 cases in group B,in the period of renal function compensation.Another 50 healthy subjects who had physical examination in our hospital in the same period were selected as group C,and the D-D level and prothrombin time(PT)of the three groups were analyzed Activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB),etc.Results The level of D-D,PT,APTT and TT in group A+B was higher than that in group C,and the level of FIB was lower than that in group C(P<0.05);the level of D-D,PT,APTT and TT in group A was lower than that in group B,and the level of FIB was higher than that in group B(P<0.05).Conclusion D-D level and PT,APTT,TT,FIB are important clinical significance in the detection of coagulation status and disease development in patients with nephrotic syndrome.

关 键 词：肾病综合征 血清D-D水平 凝血酶原时间 活化部分凝血活酶时间 凝血酶时间 纤维蛋白原 

分 类 号：R692[医药卫生—泌尿科学]