老年肺部疾病患者血清中唾液酸变化水平分析  

Analysis of sialic acid levels in patients with senile pulmonary disease

作　　者：刘沛 吴国友[1] 张亚培[1] 董世雷[1] LIU Pei;WU Guoyou;ZHANG Yapei;DONG Shilei(Department of Clinical Laboratory,Zhejiang Hospital,Zhejiang Province,Hangzhou 310000,China)

机构地区：[1]浙江医院医学检验科,浙江杭州310000

出　　处：《中国医药导报》2020年第14期122-124,130,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(81801978);浙江省医药卫生科技计划项目(2018KY201)。

摘　　要：目的初步探讨老年慢性阻塞性肺疾病(COPD)、肺炎、肺癌患者血清中唾液酸(SA)的变化程度。方法选取2017年12月~2018年12月浙江医院(以下简称“我院”)收治的274例老年患者作为观察组,根据3种疾病的诊断标准、实验室检查以及影像学检查,共分为以下三组:COPD组(74例)、肺炎组(100例)、肺癌组(100例)。以同期体检的100名健康者作为对照组。采用SA试剂盒酶法检测患者血清标本SA含量,分析肺部疾病与唾液酸变化的相关性。结果与对照组比较,COPD组、肺炎组、肺癌组血清中SA水平均升高,差异均有统计学意义(均P<0.05);肺炎组和肺癌组血清中SA水平均高于COPD组,差异有统计学意义(P<0.05);肺炎组与肺癌组血清中SA水平比较,差异无统计学意义(P>0.05)。经Pearson相关性分析发现,COPD组血清中SA水平与肺癌组呈负相关(r=-0.25,P<0.05)。结论利用酶法检测血清中SA含量,不仅为老年肺部疾病的患者提供初期的临床诊断价值,还可为疾病后续的靶向治疗提供一定的辅助作用。Objective To explore the changes of sialic acid(SA)in serum of elderly patients with chronic obstructive pulmonary disease(COPD),pneumonia and lung cancer.Methods A total of 274 elderly patients admitted to Zhejiang Hospital(“our hospital”for short)from December 2017 to December 2018 were selected as the observation group.According to the diagnostic criteria of three diseases,laboratory examination and imaging examination,they were divided into the following three groups:COPD group(74 cases),pneumonia group(100 cases),lung cancer group(100 cases).A total of 100 healthy people who were examined during the same period were used as the control group.The SA kit was used to detect the SA content in serum samples from patients,while the correlation between lung diseases and sialic acid changes were analyzed.Results Compared with the control group,serum SA levels in COPD group,pneumonia group and lung cancer group were all increased,and the differences were all statistically significant(all P<0.05).Serum SA levels in the pneumonia group and the lung cancer group were higher than those in the COPD group,with statistically significant differences(P<0.05).There was no statistically significant difference in serum SA level between the pneumonia group and the lung cancer group(P>0.05).Pearson correlation analysis showed that serum SA level in COPD group was negatively correlated with that in lung cancer group(r=-0.25,P<0.05).Conclusion The use of enzymatic detection of sialic acid in serum not only provides initial clinical diagnostic value for patients with chronic lung disease,but also provides a certain auxiliary effect for targeted therapy of disease.

关 键 词：血清唾液酸 慢性阻塞性肺疾病 肺炎 肺癌 

分 类 号：R563[医药卫生—呼吸系统]