多囊卵巢综合征患者血清骨代谢标志物水平的变化研究  

Changes of Serum Bone Transformation Markers in Patients with Polycystic Ovary Syndrome

作　　者：霍丽静[1] 于芳 马倩[1] 魏常梅 赵培[1] 帖彦清[1] 任路平[1] 杨朝菊[1] HUO Lijing;YU Fang;MA Qian;WEI Changmei;ZHAO Pei;TIE Yanqing;REN Luping;YANG Chaoju(Department of Laboratory,Hebei People’s Hospital, Shijiazhuang 050051, China)

机构地区：[1]河北省人民医院检验科,河北石家庄050051

出　　处：《标记免疫分析与临床》2020年第4期591-594,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨多囊卵巢综合征患者血清中性激素和骨代谢标志物的水平变化。方法连续收集2016年至2017年间在河北省人民医院门诊及住院新确诊的PCOS患者65例(PCOS组)及年龄相匹配的健康女性59例(正常对照组)。分别测定其血清中25-羟基维生素D[25(OH)D]、骨钙素(OC)、骨转换标志物(P1NP,β-CTX)、生物全段甲状旁腺素(PTH1-84),及各项性激素水平等相关指标,并进行相关统计分析。结果PCOS组血清中骨形成标志物(P1NP和OC),泌乳素(PRL)较正常对照组显著降低,BMI、黄体生成素(LH)、总睾酮(TT)明显高于对照组,差异均有统计学意义(P<0.05);25-羟基维生素D、骨吸收标志物(β-CTX)及生物全段甲状旁腺素两组间差异无统计学意义(P>0.05)。结论多囊卵巢综合征患者血清中雌激素LH与雄激素TT水平均较正常女性相比显著升高,骨形成标志物与健康年轻女性相比显著降低,骨形成下降。Objective The aim of this study is to explore changes of serum bone transformation marker levels in patients with polycystic ovary syndrome(PCOS).Methods A total of 65 newly diagnosed PCOS patients and 59 age-matched healthy women were collected in Hebei General Hospital from 2016 to 2017.The levels of serum 25-hydroxy vitamin D(25OHD),osteocalcin(OC),bone turnover markers(P1NP,β-CTX),biological parathyroid hormone(PTH1-84)and related sex hormone were measured in all subjects.Then statistical software was used to analyze the data.Results The serum levels of P1NP and OC in the PCOS group were significantly lower than those in the normal control group(P<0.05),whereas no significant differences were found inβ-CTX and 25OHD levels between the two groups.Conclusion The levels of serum bone formation markers in patients with PCOS are significantly decreased compared with the healthy control group,suggesting that the bone formation is decreased in PCOS patients.

关 键 词：多囊卵巢综合征 骨代谢标志物 25-羟维生素D 骨钙素 Ⅰ型前胶原氨基末端延长肽 Ⅰ型胶原羧基端肽β特殊序列 

分 类 号：R588.6[医药卫生—内分泌]