热休克蛋白对脓毒症病理机制的新认识  

A new understanding of the pathogenesis of sepsis by heat shock proteins

作　　者：潘郭海容 梁群[2] Pan Guo-hai-rong;Liang Qun(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中国急救医学》2020年第4期356-361,共6页Chinese Journal of Critical Care Medicine

基　　金：国家自然科学基金项目(81774276);哈尔滨市应用技术研究与开发项目(2017RAXXJ037);黑龙江中医药大学科研基金项目(2017XY03);黑龙江中医药大学校级科技创新研究平台项目(2018Pt06);黑龙江中医药大学“优秀创新人才支持计划”科研项目(2018RCL16)。

摘　　要：热休克蛋白(HSPs)家族作为一个庞大的糖蛋白超基因家族,其每个家族成员在机体受到应激刺激时都发挥着重要的作用.在脓毒症患者体内,当机体受到感染、炎症反应、器官衰竭等多方面威胁时,特定的HSPs家族成员将会出现表达水平、细胞定位的改变,并由此对疾病进行干预.本文着重介绍包括HSP60、HSP70、HSP90不同家族成员在应激反应中所发挥的保护细胞免受应激损伤的作用,并分析在脓毒症中HSPs调节机体免疫功能、炎症反应和组织脏器保护作用,以及脓毒症病程中特定病症(谷氨酰胺缺乏症)对HSPs表达的影响.有望通过对脓毒症中HSPs的认识,为脓毒症今后治疗研究提供新方向.The heat shock proteins(HSPs)family is a large glycoprotein supergene family,and each family member plays an important role in the body’s stress stimulation.In the patients with sepsis,when the body is threatened by infection,inflammation,organ failure and other threats,specific HSPs family members will have changes in expression levels and cell localization,and thus intervene in the disease.This article focuses on the role of different family members including HSP60,HSP70 and HSP90 in stress response to protect cells from stress damage,and analyzes these HSPs in sepsis to regulate immune function,inflammatory response and tissue organ protection,as well as the effects of specific conditions(glutamine deficiency)on HSPs expression in the course of sepsis.It is expected that the understanding of HSPs in sepsis will provide a new direction for the future prevention and treatment of sepsis.

关 键 词：脓毒症 热休克蛋白(HSPs) 免疫调节 炎症反应 

分 类 号：R459.7[医药卫生—急诊医学]