血清P物质水平与糖尿病足发病风险相关性研究  

The study on the correlation between serum substance P level and risk of diabetic foot in patient with diabetic foot

作　　者：吴志昊[1] 李微 孔祥[2] WU Zhi-hao;LI Wei;KONG Xiang(Department of Endocrinology,Bengbu 3rd People's Hospital,Bengbu,Anhui 233000,China;不详)

机构地区：[1]蚌埠市第三人民医院内分泌科,安徽蚌埠233000 [2]皖南医学院弋矶山医院内分泌科,安徽芜湖241000

出　　处：《中华全科医学》2020年第7期1115-1117,共3页Chinese Journal of General Practice

基　　金：国家自然科学基金青年项目(81600645);蚌埠市科技局项目(20140316)。

摘　　要：目的探讨糖尿病患者血清神经肽P物质(SP)与糖尿病足的相关性,以期早期诊断并进行临床干预。方法选择2017年9月—2018年11月在蚌埠市第三人民医院内分泌科接受治疗且资料完整的糖尿病患者96例,其中糖尿病足组(DF组)60例,非糖尿病足组(NDF组)36例,收集患者性别、是否吸烟、糖化血红蛋白(HbA1c)水平、糖尿病病程、SP水平等资料,采用多因素logistic回归分析筛选DF预测因素,并比较2组患者血清中SP的水平。结果吸烟(OR=8.250,95%CI:3.201~21.265,P<0.001)和SP水平(OR=9.000,95%CI:3.466~23.370,P<0.001)为DF发生的危险因素。DF组SP的平均值为(54.47±16.72)pg/mL,NDF组SP的平均值为(116.47±19.00)pg/mL,DF组患者血清SP水平显著低于NDF组(P<0.05)。DF组重度组和中度组患者血清SP水平均低于轻度组(均P<0.05)。SP的AUC为0.994,对于诊断糖尿病足有较强的诊断效能(P<0.05),Cut off值为83.30。结论吸烟和SP水平为DF发生的危险因素,SP水平与DF的严重程度呈负相关。Objective To research the correlation between substance P(SP)of serum neuropeptide and diabetic foot in diabetic patients,and to make early diagnosis and clinical intervention.Methods Total 96 cases diabetic patients with complete information were chosen in Department of Endocrinology of the 3rd People's Hospital of Bengbu from September 2017 to November 2018,in which there were 60 cases in diabetic foot group(DF)and 36 cases in non-diabetic foot(NDF)group.The data of patients'sex,smoking,glycosylated hemoglobin(HbA1c)levels,diabetes duration and SP level were collected.Multiple factors logistic regression analysis was used to screen out independent predictive factors of DF.Serum SP levels in the two groups were tested and compared.Results Multivariate logistic regression analysis indi-cated that smoking(OR=8.250,95%CI:3.201-21.265,P<0.001)and SP levels(OR=9.000,95%CI:3.466-23.370,P<0.001)were risk factors for DF.The SP level of DF group was(54.47±16.72)pg/mL,and that of NDF group was(116.47±19.00)pg/mL.The serum SP level of DF group was significantly lower than that of NDF group(P<0.05).In the DF group,the serum SP level in severe and moderate patients groups were lower than that in the mild group(all P<0.05).The AUC of SP was 0.994,which had a strong significance for the diagnosis of diabetic foot(P<0.05),and the cut off value was 83.30.Conclusion The smoking and SP level are the risk factors for DF,and SP level is negatively correlated with DF severity.

关 键 词：糖尿病足 神经肽 P物质 

分 类 号：R587.2[医药卫生—内分泌] R393[医药卫生—内科学]