G蛋白β3亚单位和去甲肾上腺素转运体基因多态性与学龄双生子儿童心理行为问题的相关性  

Correlations between gene polymorphisms of G proteinβ3 subunit and norepinephrine transporter and mental behavioral problems in school-age twins

作　　者：陈瑶[1] CHEN Yao(Department of Pediatrics,Shangluo Central Hospital,Shangluo,Shaanxi 726000,China)

机构地区：[1]商洛市中心医院儿科,陕西商洛726000

出　　处：《中国妇幼保健》2020年第10期1879-1884,共6页Maternal and Child Health Care of China

摘　　要：目的探讨G蛋白β3亚单位(GNβ3-C825T)和去甲肾上腺素转运体(NET T182)基因多态性与学龄双生子儿童心理行为问题的相关性。方法采用Achenbach儿童行为量表(CBCL)对143对6~12岁学龄双生子儿童心理行为问题进行筛查和测评,采用PCR对GNβ3-C825T和NET T182进行基因分型,采用广义估计方程对GNβ3-C825T和NET T182基因型与学龄双生子儿童的心理行为问题进行相关性分析。结果共70例学龄双生子儿童检出行为问题,检出率为24.48%。各因子中,思维问题的检出率最高(15.38%)。男童与女童行为问题各因子检出率比较差异均无统计学意义(均P>0.05)。GNβ3-C825T和各行为问题均存在明显的相关性(均P<0.05),NET T182仅和社会化问题发生情况相关(P<0.05)。GNβ3-C825T和NET T182基因均与家庭环境因素无关联。焦虑抑郁的发生主要受儿童GNβ3-C825T基因多态性的影响,含T基因的个体比不含T基因的个体更容易发生焦虑问题。同时,焦虑和抑郁的发生也受NET T182基因多态性的影响,含C基因的个体比不含C基因的个体更容易发生焦虑问题,性别对社会化问题的主效应差异有统计学意义(P<0.05),男童比女童更容易发生社会化问题。结论GNβ3-C825T和NET T182基因可能是影响双生子儿童行为问题的重要基因,与焦虑抑郁发生有一定关联,且NET T182与学龄双生子儿童社会化问题也存在一定关联。Objective To explore the correlations between gene polymorphisms of G proteinβ3 subunit(GNβ3-C825T)and norepinephrine transporter(NET T182)and mental behavioral problems in school-age twins.Methods Achenbach Child Behavior Scale(CBCL)was used to screen and evaluate 143 pairs of twins aged 6-12 years old,PCR was used for genotyping of GNβ3-C825T and NET T182,generalized estimation equation was used to analyze the correlations between GNβ3-C825T and NET T182 genotypes and mental behavioral problems of school-age twins.Results The detection rate of behavioral problems in school-age twins was 24.48%.The detection rate of thinking problem was the highest among the all factors(15.38%).There was no statistically significant difference in the detection rates of various factors of behavioral problems between boys and girls(P>0.05).GNβ3-C825T was significantly correlated with various behavioral problems(P<0.05),NET T182 was only correlated with the occurrence of social problems(P<0.05),GNβ3-C825T and NET T182 were not correlated with family environmental factors.The occurrence of anxiety and depression was mainly affected by gene polymorphism of GNβ3-C825T,the children with T gene were more likely to have anxiety problem compared with the children without T gene.The occurrence of anxiety and depression was also affected by gene polymorphism of NET T182,the children with C gene were more likely to have anxiety problem compared with the children without C gene,there was statistically significant difference in the main effect of gender on social problems(P<0.05),boys were more likely to have social problems compared with girls.Conclusion GNβ3-C825T and NET T182 genes may be important genes affecting behavioral problems of school-age twins,which are correlated with anxiety and depression to a certain extent.There is a certain correlation between NET T182 and social problems in school-age twins.

关 键 词：GNβ3-C825T NET T182 学龄双生子 行为问题 

分 类 号：R179[医药卫生—妇幼卫生保健]