磷酸钠盐口服溶液诱导痛风急性发作3例  

Sodium phosphates oral solution-induced acute attack of gout:report of 3 cases

作　　者：高薇娜 谢沂宏 Gao Weina;Xie Yihong(Department of Gastroenterology,Hospital of Chengdu Office of People′s Government of Tibet Autonomous Region,Chengdu 610041,China;Department of Pharmacy,Hospital of Chengdu Office of People′s Government of Tibet Autonomous Region,Chengdu 610041,China)

机构地区：[1]西藏自治区人民政府驻成都办事处医院消化内科,610041 [2]西藏自治区人民政府驻成都办事处医院药剂科,610041

出　　处：《药物不良反应杂志》2020年第4期264-265,共2页Adverse Drug Reactions Journal

摘　　要：3例藏族男性患者(例1,64岁;例2,51岁;例3,39岁)既往均有痛风病史,为行内镜下检查或治疗做肠道准备而服用磷酸钠盐口服溶液90 ml。服药后第2天均出现典型痛风发作,但血尿酸均比服药前下降(例1,526μmol/L降至417μmol/L;例2,566μmol/L降至374μmol/L;例3,465μmol/L降至379μmol/L)。考虑3例患者的痛风急性发作可能与磷酸钠盐口服溶液有关,是否与磷酸盐结晶相关尚不能确定。Three Tibetan male patients(patient 1,64-year-old;patient 2,51-year-old;patient 3,39-year-old)with previous history of gout received sodium phosphates oral solution 90 ml in intestinal preparation for endoscopic examination or treatment.The patients all developed typical gout attack on day 2 after their medications,but their blood uric acid levels were lower than those before taking the medicine(patient 1,from 526μmol/L to 417μmol/L;patient 2,from 566μmol/L to 374μmol/L;patient 3,from 465μmol/L to 379μmol/L),respectively.The acute attack of gout in the 3 patients was considered to be related with sodium phosphates oral solution,but whether it was related with phosphate crystallization was not determined.

关 键 词：磷酸盐类 痛风 突发症状 尿酸 结晶 

分 类 号：R589[医药卫生—内分泌]