微小RNA-29b对老年冠心病患者左心室肥厚的诊断价值  

Diagnostic value of microRNA-29b for left ventricular hypertrophy in elderly patients with coronary heart disease

作　　者：李晓静[1] 姚麒[1] 杨军[1] 陈晓敏[2] 崔翰斌[2] 徐红余[1] 张银维[1] 李文杰[1] 余晶波[1] Li Xiaojing;Yao Qi;Yang Jun;Chen Xiaomin;Cui Hanbin;Xu Hongyu;Zhang Yinwei;Li Wenjie;Yu Jingbo(Department of Geriatrics,Ningbo First Hospital,Ningbo 315010,China;Department of Cardiology,Ningbo First Hospital,Ningbo 315010,China)

机构地区：[1]浙江省宁波市第一医院老年医学科,315000 [2]浙江省宁波市第一医院心血管内科,315000

出　　处：《中华老年医学杂志》2020年第5期518-521,共4页Chinese Journal of Geriatrics

摘　　要：目的探讨微小RNA-29b对老年冠心病患者左心室肥厚(LVH)的诊断价值。方法研究对象为2015年1月至2018年12月于我院心血管内科住院的老年冠心病患者140例,其中以单纯冠心病(无LVH)患者70例作为NLVH组,以冠心病合并LVH患者70例作为LVH组,选择同期于我院进行健康检查的70例老年无冠心病人群为对照组。观察并比较3组人群之间的室间隔厚度(IVSD)、左心室后壁厚度(LVPWD)、微小RNA-29b的相对表达量;分析微小RNA-29b与IVSD、LVPWD的相关性;分析微小RNA-29b对老年冠心病伴LVH患者的诊断价值。结果3组间IVSD、LVPWD、微小RNA-29b相对表达量比较差异均具有统计学意义(F=22.838、22.147、114.096,均P=0.000);LVH组IVSD、LVPWD、微小RNA-29b的相对表达量明显高于NLVH组(t=3.479、3.206、9.852,均P=0.000),也高于对照组(t=3.904、3.553、10.792,均P=0.000);NLVH组微小RNA-29b的相对表达量明显高于对照组(t=2.306,P=0.420)。微小RNA-29b诊断老年人冠心病伴LVH的ROC曲线分析结果显示,Youden指数的最大切入点为0.80,微小RNA-29b诊断老年人冠心病伴LVH的最佳临界值为3.52,诊断LVH的敏感度为91.73%、特异度为88.27%;Pearson相关分析结果显示,微小RNA-29b表达水平与IVSD、LVPWD呈明显正相关关系(r=0.63、0.61,均P=0.000)。结论老年冠心病伴LVH患者微小RNA-29b的表达明显升高,微小RNA-29b表达水平与IVSD、LVPWD呈正相关,对老年人冠心病伴LVH诊断具有较高的灵敏度与特异度。Objective To investigate the diagnostic value of microRNA-29b(miR-29b)for left ventricular hypertrophy(LVH)in elderly patients with coronary heart disease(CHD).Methods From January 2015 to December 2018,140 elderly patients with CHD admitted in our hospital were enrolled,including 70 CHD patients without LVH(the NLVH group)and 70 CHD patients with LVH(the LVH group).Seventy healthy elderly adults without CHD who underwent heart examination at our hospital during the same period were included as the control group.The interventricular septum thickness(IVSD),left ventricular posterior wall thickness(LVPWD)and the relative expression level of microRNA-29b were detected and compared among the three groups.The correlation of microRNA-29b with IVSD and LVPWD was analyzed,and the diagnostic value of microRNA-29b for LVH in elderly CHD patients was analyzed.Results There were significant differences in IVSD,LVPWD and the relative expression level of microRNA-29b among the three groups(F=22.838,22.147 and 114.096,all P=0.000).The IVSD,LVPWD and the relative expression level of microRNA-29b were higher in the LVH group than in the NLVH group(t=3.479,3.206 and 9.852,all P=0.000)and than in the control group(t=3.904,3.553 and 10.792,all P=0.000).The relative expression level of microRNA-29b was higher in the NLVH group than in the control group(t=2.306,P=0.420).The receiver-operating characteristics(ROC)curve analysis of microRNA-29b for the diagnosis of LVH in elderly CHD patients showed that the maximum entry point of Youden index was 0.80,the optimal critical value was 3.52,the sensitivity and specificity for the diagnosis of LVH was 91.73%and 88.27%.Pearson correlation analysis showed that the expression level of microRNA-29b was positively correlated with IVSD and LVPWD(r=0.63 and 0.61,P=0.000).Conclusions The expression level of microRNA-29b is significantly increased in elderly CHD patients with LVH,and positively correlated with IVSD and LVPWD.The expression level of microRNA-29b has high sensitivity and specificity i

关 键 词：RNA 冠心病 肥大 左心室 

分 类 号：R541.4[医药卫生—心血管疾病]