骨质疏松与动脉粥样硬化:基于Ox-LDL的转导作用  

Osteoporosis and atherosclerosis:Ox-LDL based transduction

作　　者：陈彩玲 吴铁 杨亚军 崔燎 CHEN Cai-ling;WU Tei;YANG Ya-jun;CUI Liao(Dept of Pharmacology,School of Pharmacy,Guangdong Medical University,Zhanjiang Guangdong 524023,China;Guangdong Key Lab for Research and Development of Natural Drugs,Guangdong Medical University,Zhanjiang Guangdong 524023,China)

机构地区：[1]广东医科大学药学院药理学教研室,广东湛江524023 [2]广东医科大学广东天然药物研究与开发重点实验室,广东湛江524023

出　　处：《中国药理学通报》2020年第6期747-750,共4页Chinese Pharmacological Bulletin

基　　金：广东省科技计划资助项目(No 2016B030309002);国家自然科学基金资助项目(No 81273518)。

摘　　要：临床研究发现,动脉粥样硬化与骨质疏松常相伴出现,作为引起动脉粥样硬化公认的因素之一,氧化低密度脂蛋白(oxidized low density lipoprotein,Ox-LDL)是否是导致这两种疾病的启动因子?Ox-LDL对骨代谢如何影响?本文回顾了近年来在此领域的研究进展,分析了Ox-LDL在动脉粥样硬化和骨质疏松之间的转导作用,其中Ox-LDL对成骨细胞起抑制作用,从而对导致骨质疏松的机制起了重要作用,提示Ox-LDL可能是引起动脉粥样硬化和骨质疏松的关键因素。这为通过调控Ox-LDL共同治疗动脉粥样硬化与骨质疏松的药物研究提供新的思路。Clinical studies have found that atherosclerosis is often accompanied with osteoporosis.As one of the recognized factors causing atherosclerosis,is oxidized low-density lipoprotein(Ox-LDL)an initiator of these two diseases?How does Ox-LDL affect bone metabolism?This paper reviewed the research progress in this field in recent years,and analyzed the transduction role of Ox-LDL in atherosclerosis and osteoporosis,in which Ox-LDL inhibited osteoblasts and played an important role in the mechanism of osteoporosis,suggesting that Ox-LDL may be the key factor for atherosclerosis and osteoporosis.This provides a new idea for drug research on the treatment of atherosclerosis and osteoporosis by regulating Ox-LDL.

关 键 词：OX-LDL 骨质疏松 成骨细胞 动脉粥样硬化 丹参 机制 

分 类 号：R284.1[医药卫生—中药学] R336[医药卫生—中医学]