分析大黄泄浊颗粒保留灌肠对非透析慢性肾脏病肾性骨病湿热证患者骨密度及血清骨形成蛋白-7的应用价值  

Efficacy of retention enema with the Dahuang Xiezhuo granules on BMD and BMP-7 in renal osteodystrophy from non-dialysis patients with chronic kidney disease of the Shire symptom

作　　者：宋珂 Song Ke

机构地区：[1]菏泽单县海吉亚医院,山东菏泽274300

出　　处：《中医临床研究》2020年第10期17-20,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:探究临床非透析慢性肾脏病肾性骨病湿热证患者治疗中应用大黄泄浊颗粒保留灌肠对疗效的影响。方法:选取2017年7月-2018年1月期间本院接诊的非透析慢性肾脏病(Chronic Kidney Disease,CKD)肾性骨病湿热证患者64例作为研究对象。按数字表法分为研究组、常规组,排除随访失联患者后,每组均为30例患者。结果:研究组比常规组具有更显著的治疗效果,P<0.05,差异具有统计学意义。研究组的骨密度(Bone Mineral Density,BMD)和骨形成蛋白(Bone Morphogenetic Protein,BMP)-7的升高幅度明显高于常规组幅度,P<0.05,差异具有统计学意义。常规组患者的钙(Ca)、磷(P)、β2-微球蛋白(β2-microglobulin,β2-MG)水平高于研究组,P<0.05,差异均具有统计学意义。研究组、常规组相比于正常组,以上两组的血清P、尿酸(Uric Acid,UA)、全段甲状旁腺激素(intact Parathyroid Hormone,iPTH)、同型半胱氨酸(Homocysteine,Hcy)的水平更高,P<0.05,差异均具有统计学意义。两组患者的血Ca水平明显低于正常组,P<0.05,差异具有统计学意义。BMD与血P(r=-0.259,P<0.05)、iPTH(r=-0.315,P<0.05)、Hcy(r=-0.259,P<0.05)、β2-MG(r=-0.255,P<0.05)呈负相关。结论:大黄泄浊颗粒保留灌肠治疗可改善CKD患者的临床症状,提高患者治疗效果,具有极高的临床应用价值。Objective:To explore the effect of retention enema with the Dahuang Xiezhuo granule(大黄泄浊颗粒)on renal osteodystrophy from non-dialysis patients with chronic kidney disease of the Shire symptom(湿热证).Methods:64 patients were divided into the study group and routine group.Expecting losting to follow-up patients,each group with 30 patients.Results:Efficacy,BMD and BMP-7 in the study group were better than the routine group,P<0.05.The levels of Ca,P,β2-microglobulin(β2-MG)in the conventional group were higher than those in the study group,P<0.05.Serum P,UA,iPTH and Hcy were higher in the study group and routine group than the normal group,P<0.05.The Ca level in the two groups was significantly lower than that in the normal group,P<0.05.BMD and blood P(r=-0.259,P<0.05),iPTH(r=-0.315,P<0.05),Hcy(r=-0.259,P<0.05),β2-MG(r=-0.255,P<0.05)was negatively correlated.Conclusion:Retention enema with the Dahuang Xiezhuo granules can improve the clinical symptoms,and has high clinical application value.

关 键 词：慢性肾脏病 肾性骨病 大黄泄浊颗粒 骨密度 

分 类 号：R334.1[医药卫生—人体生理学]