中西医结合治疗对前列腺炎患者精浆锌及炎性因子的影响  

Clinical Significance of Integrated Chinese and Western Medicine in Seminal Plasma Zinc and Inflammatory Factors in Patients with Type Ⅲa Chronic Prostatitis

作　　者：韩兵[1] 陈明国[1] 张玉杰[1] 赵杉[1] 许华颖[1] 王明海 李志鹏 王如然[1] HAN Bing;CHEN Ming-guo;ZHANG Yu-jie;ZHAO Shan;XU Hua-ying;WANG Ming-hai;LI Zhi-peng;WANG Ru-ran(Department ofSurgery,SouthernDistrict ofGuanganmenHospital,ChinaAcademyofChineseMedical sciences,Beijing,102618,China;Department of Surgery,Chengdu Seventh People's Hospital,Chengdu,Sichuan,610041,China;Department of Surgery,Chengdu Second Hospital of Traditional Chinese Medicine,Chengdu,Sichuan,610016,China)

机构地区：[1]中国中医科学院广安门医院南区外科,北京102618 [2]成都市第七人民医院外科,四川成都610041 [3]成都市第二中医医院外科,四川成都610016

出　　处：《现代生物医学进展》2020年第6期1061-1065,共5页Progress in Modern Biomedicine

基　　金：国家科技支撑计划项目(2013BAI12B08)。

摘　　要：目的:探讨中西医结合治疗对Ⅲa型慢性前列腺炎患者精浆锌及炎性因子检测的临床意义。方法:采用回顾性研究方法,研究时间为2014年5月到2018年1月,选择在我院诊治的Ⅲa型慢性前列腺炎患者172例作为研究对象,根据治疗方法的不同分为观察组100例与对照组72例,对照组给予盐酸左氧氟沙星治疗,观察组在对照组治疗的基础上给予自拟中药熏蒸治疗,观察组与对照组治疗疗程为4周。结果:观察组与对照组的总有效率分别为95.0%和70.8%,观察组好于对照组(P<0.05)。治疗后观察组与对照组的NIH-CPSI评分、PVR、EPS IL-6与IL-8低于治疗前,Qmax和精浆锌浓度高于治疗前,观察组与对照组对比差异有统计学意义(P<0.05)。结论:自拟中药熏蒸联合盐酸左氧氟沙星对Ⅲa型慢性前列腺炎患者能提高精浆锌浓度,抑制EPS IL-6与IL-8等炎性因子的释放,改善尿动力学,缓解临床症状,从而提高治疗疗效。Objective: To explore the clinical significance of Integrated Chinese and Western Medicine in seminal plasma zinc and inflammatory factors in patients with type Ⅲa chronic prostatitis. Methods: Used the retrospective study method from May 2014 to January2018. 172 patients with type Ⅲa chronic prostatitis were selected in our hospital and were divided into the 100 cases of the observation group and the 72 cases of the control group accorded to the different treatment methods. The control group was treated with levofloxacin hydrochloride, the observation group was treated by the self made fumigation combined with levofloxacin hydrochloride, the treatment course was lasted for 4 weeks. Results: The total effective rate of the observation group and the control group were 95.0% and 70.8%,respectively, and the observation group were better than the control group(P<0.05). After treatment, the NIH-CPSI score, PVR, EPS IL-6 and IL-8 in the observation group and the control group were lower than those before treatment, Qmax and seminal plasma zinc concentration were higher than before treatment, and the difference between the observation group and the control group were statistically significant(P<0.05). Conclusion: The Integrated Chinese and Western Medicine in the treatment of patients with type Ⅲa chronic prostatitis can improve the concentration of zinc in the seminal plasma, inhibit the release of inflammatory factors of IL-6, IL-8, improve the urodynamics and relieve the clinical symptoms, so as to improve the therapeutic effect.

关 键 词：中药熏蒸 左氧氟沙星 慢性前列腺炎 精浆锌 炎性因子 

分 类 号：R697.3[医药卫生—泌尿科学] R285.5[医药卫生—外科学]