甲基化试剂的研究进展  

Recent advances in methylating agents

作　　者：赵云霏 白静宜 王敏燕 陆红健 史壮志 Yunfei Zhao;Jingyi Bai;Minyan Wang;Hongjian Lu;Zhuangzhi Shi(State Key Laboratory of Coordination Chemistry,Chemistry and Biomedicine Innovation Center(ChemBIC),School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China;Jiangsu Key Laboratory of Advanced Organic Materials,Institute of Chemistry and Biomedical Sciences,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China)

机构地区：[1]南京大学化学化工学院配位化学国家重点实验室,化学和生物医药创新研究院,南京210023 [2]南京大学化学化工学院先进有机材料江苏省重点实验室,化学和生物医药科学研究所,南京210023

出　　处：《中国科学：化学》2020年第5期526-551,共26页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21972064,21901111);江苏省自然科学基金(编号:BK20170632)资助项目。

摘　　要：甲基是生物活性分子和药物分子的重要砌块,是组成复杂分子的重要结构单元.对复杂分子进行甲基修饰一般通过甲基化反应来实现,主要有亲核进攻、亲电进攻或自由基等途径.本文通过对文献的整理和总结,介绍了过去几十年常用于甲基化反应的甲基试剂,主要包括亲电甲基化试剂和亲核甲基化试剂.重点介绍了近年来发展的新型甲基试剂和新型甲基化反应,并对其反应机理进行了探讨.我们期望本文能够帮助科研工作者了解甲基化的发展和各种甲基化方法的优缺点,从而激发他们对甲基化领域的研究兴趣.Methyl group is not only an important building block of biologically active molecules and drug molecules,but also the important structural unit of complex molecules. Methylation of complex molecules is generally achieved through methylating reactions, which mainly include nucleophilic attack, electrophilic attack, and radical pathways. This review summarized the literatures of the past few decades and covered commonly used methylating agents used in methylation. In this review, the recently developed new methylating agents and methylation reactions are highlighted,and the reaction mechanisms are also detailed discussed. We expect that this review will inspire others to devote their research in the field of methylation.

关 键 词：亲电甲基化试剂 亲核甲基化试剂 甲醇 甲基硼试剂 金属催化 

分 类 号：TQ421[化学工程]