雄性不育相关基因敲除小鼠模型  

Male infertility - related gene knockout mouse models

作　　者：李文秀[1] 边艳超(综述)[1] 任建军[1] 肖瑞(审校)[1] LI Wen-xiu;BIAN Yan-chao;REN Jian-jun;XIAO Rui(Key Laboratory of Molecular Pathology,Inner Mongolia Medical University,Hohhot,Inner Mongolia 010000,China)

机构地区：[1]内蒙古医科大学内蒙古自治区分子病理学重点实验室,内蒙古呼和浩特010000

出　　处：《中华男科学杂志》2020年第4期357-363,共7页National Journal of Andrology

基　　金：国家自然科学基金(31260260,31760304);内蒙古自治区自然科学基金项目(2015MS0372)。

摘　　要：男性不育的发生机制复杂,建立雄性不育的动物模型,特别是小鼠模型,为研究不育相关基因功能和分子机制提供了模型基础,目前用于生物医学研究的小鼠模型主要有3种类型,例如敲除/敲入/基因捕获方法获得小鼠,转基因小鼠和化学诱导的点突变小鼠。本文对雄性不育相关基因敲除的小鼠模型进行了总结,以期为研究男性不育的发病机制寻找合适的动物模型。The pathogenesis of male infertility is rather complicated. The establishment of animal models, especially mouse models, of male infertility, provides a model basis for the studies of the roles and molecular mechanisms of infertility-related genes. Currently there are mainly three types of mouse models for biomedical researches, namely, the mouse model made by the knockout, knock-in or gene capture method, transgenic mouse model, and chemically induced point mutant mouse model. This review summarizes male infertility - related gene knockout mouse models, aiming to find a suitable animal model for studying the pathogenesis of male infertility.

关 键 词：男性不育 基因敲除小鼠模型 

分 类 号：R698[医药卫生—泌尿科学]