中国成年双生子人群的冠心病遗传度估计  

Heritability of coronary heart disease,based on the data from the Chinese adult twins

作　　者：王冬萌 高文静[1] 吕筠[1] 余灿清[1] 王胜锋[1] 逄增昌[2] 俞敏[3] 汪华[4] 吴先萍[5] 董忠[6] 吴凡[7] 江国虹[8] 王晓节[9] 刘彧[10] 邓健[11] 陆林[12] 曹卫华[1] 李立明[1] Wang Dongmeng;Gao Wenjing;Lyu Jun;Yu Canqing;Wang Shengfeng;Pang Zengchang;Yu Min;Wang Hua;Wu Xianping;Dong Zhong;Wu Fan;Jiang Guohong;Wang Xiaojie;Liu Yu;Deng Jian;Lu Lin;Cao Weihua;Li Liming(Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Qingdao Center for Disease Control and Prevention,Qingdao 266033,China;Zhejiang Center for Disease Control and Prevention,Hangzhou 310051,China;Jiangsu Center for Disease Control and Prevention,Nanjing 210009,China;Sichuan Center for Disease Control and Prevention,Chengdu 610041,China;Beijing Center for Disease Prevention and Control,Beijing 100013,China;Shanghai Municipal Center for Disease Control&Prevention,Shanghai 200336,China;Tianjin Centers for Diseases Control and Prevention,Tianjin 300011,China;Qinghai Center for Disease Control and Prevention,Xining 810007,China;Heilongjiang Agricultural Center for Disease Control and Prevention,Harbin 150090,China;Handan Center for Disease Control and Prevention,Handan 056001,China;Yunnan Center for Disease Control and Prevention,Kunming 650034,China)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,100191 [2]青岛市疾病预防控制中心,266033 [3]浙江省疾病预防控制中心,杭州310051 [4]江苏省疾病预防控制中心,南京210009 [5]四川省疾病预防控制中心,成都610041 [6]北京市疾病预防控制中心,100013 [7]上海市疾病预防控制中心,200336 [8]天津市疾病预防控制中心,300011 [9]青海省疾病预防控制中心,西宁810007 [10]黑龙江省农垦总局疾病预防控制中心,哈尔滨150090 [11]邯郸市疾病预防控制中心,056001 [12]云南省疾病预防控制中心,昆明650034

出　　处：《中华流行病学杂志》2020年第5期700-704,共5页Chinese Journal of Epidemiology

基　　金：公益性行业科研专项(201502006,201002007);国家自然科学基金(81711530051)。

摘　　要：目的分析中国成年双生子人群的冠心病遗传度。方法利用中国双生子登记系统在11省、市募集的20477对≥25岁同性别双生子,构建结构方程模型计算遗传度。结果调整年龄、性别后,冠心病的遗传度为0.75(0.68~0.81)。亚组分析显示≥40岁组和女性人群中,冠心病患病主要受遗传因素的影响;而25~39岁组和男性的患病主要受环境因素的影响。结论冠心病患病受遗传和环境因素的影响,且遗传度较高。Objective To analyze the heritability of coronary heart disease(CHD)among the Chinese twin adults.Methods A total of 20477 same-sex twin pairs aged 25 years and older from the Chinese National Twin Registry were interviewed.Structure equation model was used to estimate the heritability of CHD.Results After adjusting for age and gender,the overall heritability of CHD was 0.75(0.68-0.81).Stratified analyses showed that genetic factors play a more important role in CHD incidence in≥40 years or female twins.While the development of CHD was mainly influenced by environmental factors in 25-39 years or male twins.Conclusion CHD is influenced by both genetic and environmental factors and the heritability is high.

关 键 词：冠心病 双生子研究 遗传度 

分 类 号：R541[医药卫生—心血管疾病]