原发性结节型皮肤淀粉样变性  

A case of primary nodular cutaneous amyloidosis

作　　者：高薇 曾学思[2] 王洪生[2] 张倩[2] GAO Wei;ZENG Xue-si;WANG Hong-sheng;ZHANG Qian(Department of Dermatology,The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213003,China)

机构地区：[1]南京医科大学附属常州第二人民医院皮肤科,江苏常州213003 [2]中国医学科学院北京协和医学院皮肤病研究所,江苏南京210042

出　　处：《临床皮肤科杂志》2020年第5期276-277,共2页Journal of Clinical Dermatology

摘　　要：报告1例原发性结节型皮肤淀粉样变性。患者男,41岁,双侧鼻孔缘下斑块、结节4年就诊,无自觉症状。组织病理检查:表皮基底细胞轻度液化变性,真皮浅、深层及皮下组织胶原纤维间可见嗜酸性物沉积,血管壁见类似改变。结晶紫和刚果红染色阳性,PAS染色弱阳性,偏振光显微镜下呈苹果绿双折光。诊断:原发性结节型皮肤淀粉样变性。A case of primary nodular cutaneous amyloidosis is reported. The patient was a 41-year-old man who developed asymptomatic plaques and nodules under bilateral nostrils 4 years ago. Histopathological examination showed mild liquefaction degeneration of basal cells in the epidermis, eosinophilic deposit in the superficial and deep layers of dermis, subcutaneous collagen fibers and vascular wall. Crystal violet and Congo red staining showed positive results, and PAS staining was weakly positive. Polarized light microscope showed apple green double refraction. The patient was diagnosed with primary nodular cutaneous amyloidosis.

关 键 词：皮肤淀粉样变性 原发性 结节型 

分 类 号：R758.4[医药卫生—皮肤病学与性病学]