丁苯酞对血管性轻度认知功能障碍患者肿瘤坏死因子-α和白介素-8及血尿酸的影响  

Effects of butylphthalide on serum levels of TNF-α, IL-8 and serum uric acid in the treatment of vascular congnitive impairment

作　　者：孙彦杰[1] 刘娜[2] 李欣[3] 段瑞生[4] SUN Yan-jie;LIU Na;LI Xin;DUAN Rui-sheng(The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Shjiazhuang Medical College,Shijiazhuang 050000,China;Shijiazhuang Great Wall Hospital of Integrated Traditional Chinese and Western Medicine,Shijazhuang 050000,China;Hebei General Hospital,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院,石家庄050000 [2]石家庄医学高等专科学校,石家庄050000 [3]石家庄长城中西医结合医院,石家庄050000 [4]河北省人民医院,石家庄050000

出　　处：《中国新药杂志》2020年第6期651-654,共4页Chinese Journal of New Drugs

基　　金：河北省卫健委医学科学研究青年科技课题(20180340)。

摘　　要：目的:探讨丁苯酞软胶囊治疗血管性轻度认知功能障碍(vascular congnitive impairment,VCI)的临床疗效以及对血浆肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、白细胞介素-8(inter leukin-8,IL-8)浓度和血尿酸的影响。方法:将60例血管性轻度认知障碍患者(按随机数字表法)随机分为两组,每组30例,治疗组给予基础药物治疗加口服丁苯酞软胶囊治疗,对照组给予基础药物,疗程为12个月,于治疗前、治疗后第6个月、第12个月分别对患者进行简易精神状态检查(mini-mental state examination,MMSE),测定TNF-α和IL-8浓度。于治疗前、治疗后第3个月分别对患者血尿酸水平进行检测。结果:治疗组6个月、12个月时MMSE评分与对照组比较有明显改善(P<0.05),TNF-α和IL-8浓度显著下降(P<0.05);治疗组3个月时患者血尿酸水平明显低于对照组(P<0.05)。结论:丁苯酞软胶囊可有效提高血管性轻度认知功能障碍患者MMSE评分并降低TNF-α和IL-8浓度,具有神经保护作用;丁苯酞软胶囊可显著降低血尿酸水平。Objective: To investigate the effects of butylphthalide in the treatment of vascular congnitive impairment(VCI) and on the serum levels of tumor necrosis factor-α(TNF-α), inter leukin-8(IL-8) and serum uric acid. Methods:Sixty VCI patients were randomly divided into treatment group and control group, with 30 patients in each group. On the basis of routine treatment, the patients in the treatment group were treated by butylphthalide for 12 months,while the patients in the control group were given basic treatment.The therapeutic effects were evaluated by using MMSE scale and the serum levels of TNF-α and IL-8 were observed before treatment and at 6 and 12 months after treatment in both groups.Serum uric acid levels were measured before treatment and 3 months after treatment. Results:In the treatment group, the MMSE scores were obviously improved(P<0.05), and the serum levels of TNF-α and IL-8 were significantly decreased(P<0.05) than the control group after 6 and 12 months treatment.The serum uric acid level of the patients in the treatment group was significantly lower than that of the control group at 3 months. Conclusion: Butylphthalide can improve the MMSE score of VCI patients,which may be correlated with the down-regulation of the serum levels of TNF-α and IL-8.Butylphthalide soft capsules can significantly reduce serum uric acid levels.

关 键 词：血管性轻度认知功能障碍 丁苯酞 肿瘤坏死因子-Α 白介素-8 血尿酸 

分 类 号：R969.4[医药卫生—药理学]