中药泡洗治疗卡培他滨相关重度手足综合征1例并文献回顾  

Treatment of severe hand and foot syndrome caused by capecitabine with traditional Chinese medicine soaking: a case report and literature review

作　　者：张静怡 崔慧娟[2] 彭艳梅[1] 李嫱[1] 申文[1] 张旭[1] 孙晨耀 ZHANG Jing-yi;CUI Hui-juan;PENG Yan-mei;LI Qiang;SHEN Wen;ZHANG Xu;SUN Chen-yao(Beijing University of Chinese Medicine,Beijing 100029,China;China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院,北京100029

出　　处：《中国新药杂志》2020年第7期826-830,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金项目(81873396);首都卫生发展科研专项项目(首发2018-2-4065);中日友好医院院级课题(2016-2-QN-16)。

摘　　要：卡培他滨作为氟尿嘧啶类细胞毒药物,以手足综合征(hand and foot syndrome,HFS)为主要的不良反应,发生率相对较高,但重度的HFS发生率很低。HFS多表现为麻木、感觉异常,甚者表现为皮肤肿痛、水泡、脱皮等。卡培他滨引起HFS的发生机制仍在探讨中,现有研究认为与基因多态性、维生素B6缺乏、炎症反应等原因相关。基于此HFS的治疗措施亦不统一。文章通过报道中药泡洗治疗1例卡培他滨引起的以足底水泡破溃流脓,足跟外侧破溃流血为主要表现的重度HFS,对HFS的发生机制、中西医治疗策略进行了回顾总结。As a fluorouracil cytotoxic drug, capecitabine has a relatively high incidence of hand and foot syndrome(HFS) as the major adverse reaction, but the incidence of severe HFS is very low. HFS is characterized by numbness, abnormal sensation, and even skin swelling and pain, blisters, peeling, and so on. The mechanism of capecitabine-induced HFS is still under discussion. Current studies suggest that it is related to gene polymorphism, vitamin B6 deficiency, inflammation and so on. Therapeutic measures are thus not uniform. This paper reports a case of capecitabine-induced severe HFS, which is characterized by ulceration and purulence of sole blisters and hemorrhage of lateral heel, treated by soaking with traditional Chinese medicine. The mechanism of HFS and the treatment strategies of traditional Chinese medicine and Western medicine are reviewed and summarized.

关 键 词：手足综合征 卡培他滨 中医药 发生机制 治疗策略 

分 类 号：R273[医药卫生—中西医结合] R969[医药卫生—中医肿瘤科]