免疫控制与慢性乙型肝炎功能性治愈的进展与挑战  

Advances and challenges in immune control and functional cure of chronic hepatitis B

作　　者：郑昕[1] 刘嘉[1] 吴珺[1] 孟忠吉[2] 陆蒙吉[3] 杨东亮[1] ZHENG Xin;LIU Jia;WU Jun(Department of Infectious Diseases, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China)

机构地区：[1]华中科技大学同济医学院附属协和医院感染病科,武汉430022 [2]湖北医药学院附属太和医院感染病科,湖北十堰442008 [3]德国杜伊斯堡-埃森大学医学院病毒研究所,德国埃森45122

出　　处：《临床肝胆病杂志》2020年第5期961-964,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81461130019,81672022,91742114,8181101231,91642118);国家传染病防治科技重大专项(2017ZX10202202,2017ZX10202201,2017ZX10202203,2018ZX10302206,2018ZX10723203)。

摘　　要：HBV与宿主免疫系统的相互作用决定了HBV感染的结局。虽然迄今尚无彻底根治乙型肝炎的药物,但是随着研究的深入,以血清HBsAg和HBV DNA持续阴转为特征的“功能性治愈”已成为慢性乙型肝炎的可实现治疗目标。而基于对HBV感染免疫控制机制新认识的免疫调控治疗也成为实现慢性乙型肝炎功能性治愈的重要策略之一。本文仅就HBV感染免疫控制及其在功能性治愈策略研究中应用的进展与存在问题做一简要综述。The clinical outcome of hepatitis B virus(HBV)infection mostly depends on the interaction between HBV and host immune system.Although there are still no drugs for the radical treatment of hepatitis B at present,more and more studies have found that functional cure,characterized by persistent negative conversion of HBsAg and HBV DNA in serum,has become an achievable goal for the treatment of chronic hepatitis B.Meanwhile,immunoregulatory therapy based on a new understanding of the mechanism of immune control of HBV infection has been used as one of the important strategies for functional cure of chronic hepatitis B.This article elaborates on the immune control of HBV infection and the advances and challenges of its application in the research on the strategies for functional cure.

关 键 词：乙型肝炎 慢性 免疫调节 功能性治愈 

分 类 号：R512.62[医药卫生—内科学]