肝内固有抗原递呈细胞调控抗HBV免疫应答的作用及机制  

Role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating anti-hepatitis B virus immune response

作　　者：谢晓红 杨东亮[1] 刘嘉[1] XIE Xiaohong;YANG Dongliang;LIU Jia(Department of Infectious Diseases, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China)

机构地区：[1]华中科技大学同济医学院附属协和医院感染科,武汉430022

出　　处：《临床肝胆病杂志》2020年第5期965-970,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(81861138044,91742114);国家科技重大专项资助项目(2017ZX10202203)。

摘　　要：肝脏具有独特的免疫微环境,其内固有的抗原递呈细胞构成相互协作的网络,精密调控着肝脏免疫耐受和免疫应答之间的平衡。在HBV感染过程中,一方面病毒可利用肝内固有抗原递呈细胞诱导免疫耐受的特性逃避免疫系统对其的清除效应,形成持续性感染;另一方面,肝内固有抗原递呈细胞的功能成熟和活化也可介导有效抗乙型肝炎免疫应答的发生,从而清除病毒感染。就肝内固有抗原递呈细胞调控抗乙型肝炎免疫应答的作用及机制研究进展加以阐述。The liver has a unique immune microenvironment,and the intrinsic antigen-presenting cells in the liver interact with each other and form a network to accurately regulate the homeostasis between liver immune tolerance and immune response.During hepatitis B virus(HBV)infection,on the one hand,the intrahepatic intrinsic antigen-presenting cells induce immune tolerance to help the virus escape immune clearance and thus result in persistent infection;on the other hand,the maturation and activation of the intrahepatic intrinsic antigen-presenting cells can also mediate effective anti-HBV immune response to achieve virus clearance.This article elaborates on the research advances in the role and mechanism of action of intrahepatic intrinsic antigen-presenting cells in regulating immune response against HBV infection.

关 键 词：乙型肝炎病毒 乙型肝炎 慢性 抗原呈递细胞 肝窦内皮细胞 枯否细胞 

分 类 号：R512.62[医药卫生—内科学]